Cover Image

A Comparison of Intelligence Quotient in Children with and without β-Thalassemia Major

Samaneh Homayouni Meymandi, Sayed Hamid Seyednezhad-Golkhatmi, Mandana Homayouni Meymandi

Background: Thalassemia is the most common hemoglobinopathy worldwide. Children with β-thalassemia major have several risk factors for cognitive problems. The aim of this study is to evaluate intelligence quotient in children with β-thalassemia major and healthy counterparts using Wechsler Intelligence Scale. Materials and Methods: Within a case-control design and using convenience sampling method, the present study was carried out in Zahedan and Shiraz in 2012. Participants were matched based on their age, gender and city of residence (40 children with β-thalassemia major and 40 healthy children aging 6 to 12 years. Wechsler Intelligence Scale Revised (WISC-R) was used to find the participants’ Verbal Performance and Full intelligence scores. The scores of the two groups were then compared using descriptive analysis and independent t-test. Results: As compared with their healthy counterparts, children with β-thalassemia major had lower scores on both Verbal Scale and Full Scale (P<0.01); however, the difference between the two groups’ scores on Performance Scale fell short of significance. Conclusions: Intelligence decline does not necessarily occur in children with β-thalassemia. They are just slightly lower than their healthy counterarts and they need to receive more attention in education in order to improve. [GMJ.2015;4(4):130-31]

Thalassemia; β-Thalassemia; Intelligence Quotient; Cognitive Function; Children

Kiani AA, Mortazavi Y, Zeinali S, Shirkhani Y. The molecular analysis of beta-thalassemia mutations in Lorestan Province, Iran. Hemoglobin. 2007;31(3):343-9.

Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005;353(11):1135-46.

Kutlar F. Diagnostic approach to hemoglobinopathies. Hemoglobin. 2007;31(2):243-50.

Rezaee AR, Banoei MM, Khalili E, Houshmand M. Beta-Thalassemia in Iran: new insight into the role of genetic admixture and migration. ScientificWorldJournal. 2012;2012:635183.

Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010;5:11.

Taher AT, Otrock ZK, Uthman I, Cappellini MD. Thalassemia and hypercoagulability. Blood Rev. 2008;22(5):283-92.

Monastero R, Monastero G, Ciaccio C, Padovani A, Camarda R. Cognitive deficits in beta-thalassemia major. Acta Neurol Scand. 2000;102(3):162-8.

Atiq M, Bana M, Ahmed US, Bano S, Yousuf M, Fadoo Z, et al. Cardiac disease in beta-thalassaemia major: Is it reversible? Singapore Med J. 2006;47(8):693-6.

Chen SH, Liang DC, Lin HC, Cheng SY, Chen LJ, Liu HC. Auditory and visual toxicity during deferoxamine therapy in transfusion-dependent patients. J Pediatr Hematol Oncol. 2005;27(12):651-3.

Moayeri H, Oloomi Z. Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta-thalassemia major. Arch Iran Med. 2006;9(4):329-34.

Wong V, Li A, Lee AC. Neurophysiologic study of beta-thalassemia patients. J Child Neurol. 1993;8(4):330-5.

Incorpora G, Di Gregorio F, Romeo MA, Pavone P, Trifiletti RR, Parano E. Focal neurological deficits in children with beta-thalassemia major. Neuropediatrics. 1999;30(1):45-8.

Metafratzi Z, Argyropoulou MI, Kiortsis DN, Tsampoulas C, Chaliassos N, Efremidis SC. T(2) relaxation rate of basal ganglia and cortex in patients with beta-thalassaemia major. Br J Radiol. 2001;74(881):407-10.

Economou M, Zafeiriou DI, Kontopoulos E, Gompakis N, Koussi A, Perifanis V, et al. Neurophysiologic and intellectual evaluation of beta-thalassemia patients. Brain Dev. 2006;28(1):14-8.

Zafeiriou DI, Economou M, Athanasiou-Metaxa M. Neurological complications in beta-thalassemia. Brain Dev. 2006;28(8):477-81.

Naidenova XJ. Piaget’s theory of intelligence: operational aspect. Computer Science Journal of Moldova. 2001; 2(26):208-30.

Qasemzadeh MJ, Pirnia SA, Mohebi S, Ebrahimi SM, Ebrahimi H, Ebrahimi H, et al. Correlation of Intelligence Quotient (IQ) of Children Younger than 12 Years Old with History of Preterm Birth. Galen medical journal. 2013; 2(3):120-5.

Karimi M, Yarmohammadi H, Cappellini MD. Analysis of intelligence quotient in patients with homozygous beta-thalassemia. Saudi Med J. 2006;27(7):982-5.

Duman O, Arayici S, Fettahoglu C, Eryilmaz N, Ozkaynak S, Yesilipek A, et al. Neurocognitive function in patients with beta-thalassemia major. Pediatr Int. 2011;53(4):519-23.

Vichinsky EP, Neumayr LD, Gold JI, Weiner MW, Rule RR, Truran D, et al. Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA. 2010;303(18):1823-31.

Zafeiriou DI, Prengler M, Gombakis N, Kouskouras K, Economou M, Kardoulas A, et al. Central nervous system abnormalities in asymptomatic young patients with Sbeta-thalassemia. Ann Neurol. 2004;55(6):835-9.

Nevruz O, Ulas U, Cetin T, Kutukcu Y, Kurekci A. Cognitive dysfunction in beta-thalassemia minor. Am J Hematol. 2007;82(3):203-7.

Shahim S. Application of the Wechsler Intelligence Scale for Children-Revised (WISC-R) in Iran. psychological research journal. 1993;1(3-4):28-39.

Shahim S. Standardization Wechsler Intelligence Scale for Children in Shiraz. Social Sciences and Humanities University of Shiraz journal. 1993;7(1-2):123-53.

Canatan D, Ratip S, Kaptan S, Cosan R. Psychosocial burden of beta-thalassaemia major in Antalya, south Turkey. Soc Sci Med. 2003;56(4):815-9.

Pakbaz Z, Treadwell M, Yamashita R, Quirolo K, Foote D, Quill L, et al. Quality of life in patients with thalassemia intermedia compared to thalassemia major. Ann N Y Acad Sci. 2005;1054:457-61

Refbacks

  • There are currently no refbacks.