The Predictive Value of Endometrial Thickness in Endometrial Pathologies in Premenopausal Women with Abnormal Uterine Bleeding

  • Roksana Darabi Department of Obstetrics and Gynecology, Bouali hospital, Islamic Azad University, Tehran Medical branch, Iran.
  • Mitra Mohit Department of Obstetrics and Gynecology, Bouali hospital, Islamic Azad University, Tehran Medical branch, Iran.
  • Hengameh Mohammadkhani Student Research Committee, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  • Fathemeh Mohammadyari Department of Obstetrics and Gynecology, Bouali hospital, Islamic Azad University, Tehran Medical branch, Iran.
  • Soheila Yadollah-Damavandi Student Research Committee, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
DOI: https://doi.org/10.31661/gmj.v2i4.111
Keywords: Uterine Bleeding, Pre-menopause, Vaginal ultrasonography, Dilatation, Curettage

Abstract

AbstractBackground: Abnormal uterine bleeding (AUB) is one of the most common complains in women of any age seeking gynecologic health care and needs early diagnosis and proper management due to its impacts on the quality of life. This study was conducted to investigate the cut-off value of endometrial thickness (ET) by trans-vaginal ultra-sonography (TVUS) and evaluate its accuracy in the diagnosis of the endometrial abnormalities in premenopausal women with AUB.Materials and Methods: In this descriptive  study, 64 married women between 35-50 years old were evaluated due to AUB during 2011-2012; TVUS and fractional curettage were done. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of the ET were calculated in different cut-off values.Results: The pathological evaluations of the biopsies were normal in 37 (57.8%) patients and were abnormal in 27 (42.2%) patients, 19 endometrial polyps, 6 hyperplastic lesions and 2 endometrial cancers. ET=4 mm had 100% sensitivity, 100% NPV, 10% specificity and 28% PPV in the detection of endometrial abnormalities. ET<10 mm had a proper sensitivity (67%-100%) and NPV (78.6%-100%) but specificity was low (%10-%44). ET=10 mm with sensitivity=63%, specificity=60%, NPV=65.8% and PPV=48.2% was introduced as the cut-off point with the best area under curve (LR+=2.22 LR- =0.77).Conclusion: Although an ET<10 mm was less likely to be associated with an endometrial abnormality, the low PPV of ET and low area under ROC curve shows sonography has high false positivity in premenopausal women. ET≤4 mm was more reliable and could reduce unnecessary biopsies.

Author Biography

Roksana Darabi, Department of Obstetrics and Gynecology, Bouali hospital, Islamic Azad University, Tehran Medical branch, Iran.
Department of Obstetrics and Gynecology ,Islamic Azad University Tehran Medical Branch Iran

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Published
2013-12-01
How to Cite
Darabi, R., Mohit, M., Mohammadkhani, H., Mohammadyari, F., & Yadollah-Damavandi, S. (2013). The Predictive Value of Endometrial Thickness in Endometrial Pathologies in Premenopausal Women with Abnormal Uterine Bleeding. Galen Medical Journal, 2(4), 141-145. https://doi.org/10.31661/gmj.v2i4.111
Issue
Vol. 2 No. 4 (2013): December 2013
Section
Original Article

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