Interleukin-4 mRNA Expression in Laryngeal Squamous Cell Carcinoma Patients with or without Lymph Node Involvement

Esmael Amirazodi, Mahboobeh Razmkhah, Mansoureh Jaberipour, Ahmad Hosseini, Bijan Khademi

Background: Interleukin (IL)-4 is a member of T helper 2 (Th2) axis produced by T-lymphocyte and mast cell. It has been shown that IL-4 expression changes in tumor tissues. The main objective of this study is to investigate the expression of IL-4 mRNA in patients with Laryngeal Squamous Cell Carcinoma (LSCC) with or without lymph node involvement.

Materials and Methods: mRNA expression of IL-4 in LSCC tissues were detected by quantative Real-Time PCR (qRT-PCR). Expression of IL-4 gene was compared between lymph node positive and negative patients with Squamous Cell Carcinoma of Larynx.

Results: No statistically significant association was found in expression of IL-4 between lymph node positive and negative patients.

Conclusion: It seems that IL-4 has no important effect on the involvement of lymph node in LSCC. However, to achieve a definite conclusion more investigations are certainly required.

Cancer; Interleukin-4; Lymph Node Metastasis; Larynx; T helper 2

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