1593

Received 2019-05-21

Revised 2019-07-14

Accepted 2019-07-25

Analgesic Medicinal Plants in Shahrekord, Southwest of Iran: An Ethnobotanical Study

Gholam Basati1, Saber Abbaszadeh2,3,4, Arqavan Zebardast5, Hassan Teimouri6

1 Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran

2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

3 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

4 Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

5 Student Research Committee, Babol University of Medical Sciences, Babol, Iran

6 Department of Anesthesiology, Lorestan University of Medical Sciences, Khorramabad, Iran

Introduction

Pain is one of the main causes of disability, anxiety, and job loss [1]. Pain refers to an unpleasant sensory experience that is caused by actual or potential tissue damage [2, 3]. In fact, pain serves as a protective mechanism for the body to exhibit an appropriate response to remove the causative agent of pain and is also used for diagnosis of diseases [4]. Analgesics are of two types: opioids and non-opioids [5]. Analgesics relieve pain by disturbing the consciousness or changing other sensory receptors through central or peripheral mechanisms [6]. Opioids are strong analgesics but can lead to substantial side effects. To reduce the harmful effects of opioids, a combination of opioid and non-opioid analgesic, such as acetaminophen or aspirin, is used in most cases. Tramadol is also an opioid analgesic that acts by increasing catecholamine, in addition to activating serotonin receptors, in the central nervous system [7, 8]. Corticosterosids are another class of medicines that reduce pain and inflammation by stopping the inflammatory chain through inhibiting the phospholipase enzyme, but they are used in certain conditions such as immunosuppression and delayed tissue repair [9]. Neurological diseases including anxiety, stress, depression, insomnia, and pain due to various diseases have a relatively high prevalence and decrease the quality of life of the affected individuals [10-12]. Over the past decade, interest in various types of complementary medicine and herbal medicine has been increasing around the world [13-19]. Medicinal plants are a rich source of bioactive ingredients that are used to treat various diseases [20-24], including mental disorders such as anxiety, stress, depression, and various types of pains like headache, migraine, and toothache [23-25]. One of the controversial issues regarding medicinal plants is local knowledge. This knowledge is very extensive and includes various domains, including the ethnobotany of medicinal plants. Ethnobotany refers to the knowledge of humans about the botany and ecology of the plants’ environment. Given the ecological diversity of Iran, identification of indigenous plants across the country and gathering of information regarding the shapes and uses of these plants can help find out their pharmacological activities and their benefits for the community’s healthcare system. In this study, an ethnobotanical investigation was conducted in Shahrekord city, southwest of Iran, to study the ethnobotanical knowledge about analgesic medicinal plants and the methods of using them in the region. Since older people, including traditional therapists, mainly possess this knowledge that may be lost with their death, we enrolled 29 traditional therapists in Shahrekord to collect the information in question.

Materials and Methods

Studied region

Shahrekord city is the capital of Chaharmahal and Bakhtiari province with an area of around 2006 km2, accounting for 12% of the total area of the province. According to the 2011 Iranian Population and Housing Census report, the township of Shahrekord has 283210 inhabitants, of whom 253629 people live in urban areas, and 29581 ones live in rural areas. Three dialects are spoken in the city, i.e., Persian, Lori Bakhtiari, and Turkish. The main occupations of the people of this region are agriculture and animal husbandry. Shahrekord’s map is shown in Figure-1.

Data Collection

In this ethnobotanical study, traditional knowledge of the participants was collected using a questionnaire in 2018. To this end, the local knowledge of 29 traditional therapists in Shahrekord about the analgesic effects of medicinal plants was drawn with face-to-face interviews and a questionnaire. The questionnaire that had already been prepared was administered to the traditional therapists by the interviewers. The questionnaire included information about the location and demographic characteristics of the respondent and the local name(s) of the plant(s) and the organ(s) used. The interviewers personally referred to the respondents to elicit and record their beliefs about herbal medicine. Among the 29 traditional therapists, eight individuals were female, and 21 ones were male. The education level of the respondents was from high school diploma to master’s degree. The data drawn from the questionnaires were carefully tabulated. Data analysis was performed by the Excel software. In this study, the frequency of plant use was calculated by the equation below:

Frequency of used=(Number of people who have mentioned the plant effect / total number of people who filled out questionnaires) × 100

Results

The results showed that in Shahrekord, 23 species of medicinal plants are used to relieve pain. As shown in Table-1, the highest frequency of use was obtained for Eugenia caryophylata (44%), followed by Alhagi maurorum (31%), Tribulus terrestris (27%), and ngustifolia (24%). Other information is presented in Table-1. The most frequently used organ of the plants for the analgesic property is flower (25%), followed by stem (22%), leaves (19%), aerial organs (14%), seed (11%), root (6%), and bulb (3%). As shown in Figure-2, the Laminaceae family (n=7 species) is the plant family including the highest number of medicinal plants that are used to relieve pain in the studied region.

Discussion


Plants have always played a substantial role in the health and well-being of human societies. The beneficial effects of the plants, reported in our study, on various diseases have been confirmed by numerous trials [26-32].
Lavandula officinalis induces analgesia by affecting inflammatory processes [33]. Melissa officinalis has a central analgesic mechanism [34]. Origanum vulgare L. shows analgesic effect due to its antioxidant compounds. This plant produces analgesic effect through inflammatory processes and opioid receptors [35]. Satureja bachtiarica Bung. exerts its analgesic effect through central mechanisms and inflammatory processes [36]. Mentha piperita produces analgesic effect through both central and peripheral effects [37]. Tanacetum parthenium exhibits analgesic effect through inflammatory processes [38]. Hyoscyamus niger produces analgesic effect through cholinergic and opioid mechanisms [38]. Cinnamomum verum exerts analgesic effect through prostaglandins and stimulation of opioid receptors [40]. Zingiber officinale produces an analgesic effect by inhibiting the release of peripheral mediators and cytokines [41]. Anthemis hyalina DC. also produces analgesic effect through inflammatory processes [42]. Each plant may relieve pain through a specific mechanism of analgesic action. Pain is associated with an increase in oxidative stress, and the antioxidant plant extracts can relieve pain. These and many other plants have been shown to possess antioxidant properties [43-45]. Therefore, they may also act through this mechanism.

Conclusion

Based on the ethnobotanical knowledge in Shahrekord, several medicinal plants can be used as pain relievers due to certain pharmacological action mechanisms. The sedative and analgesic effects of some of these plants have already been reported. Regarding the difference in the ethnobotany of medicinal plants between the people of Shahrekord and those of other regions across Iran and different uses of different medicinal plants, as well as the availability of certain medicinal plants in the studied area, our findings on the knowledge of the indigenous people in Shahrekord about the use of medicinal plants may be useful. Besides, some medicinal plants used to relieve pain have not yet been adequately studied for this pharmacological activity. Therefore, if this therapeutic approach is chosen, the side effects of the plant(s) must be taken into account because medicinal plants are not completely harmless and their efficacy has not yet been definitely approved. Therefore, they should be investigated in well-designed clinical trials.

Conflict of Interest

The authors declare no conflict of interest.

Abstract

Background: Identification of indigenous medicinal plants, including the gathering of information regarding the uses of these plants can help find out their traditional pharmacological activities and their benefits for the community’s healthcare system. In this study, an ethnobotanical investigation was conducted in Shahrekord city, southwest of Iran to indicate the ethnobotanical knowledge about analgesic medicinal plants in the region and the methods of using them. Materials and Methods: To this end, plant antioxidants and analgesic medicinal plants were identified. For this purpose, a questionnaire was used to obtain indigenous knowledge from traditional therapists in Shahrekord regarding pain relief using medicinal plants. This ethnobotanical study was conducted in 2018 with the participation of 29 traditional therapists of the region under purpose. Finally, the data drawn from the questionnaires were analyzed using the Excel software. The frequency of plants use was also calculated. Results: Our study showed that in Shahrekord, 23 species of medicinal plants are used to relieve pain. The highest frequency of use was obtained for Eugenia caryophylata (44%), followed by Alhagi maurorum (31%), Tribulus terrestris (27%), and angustifolia (24%). The Laminaceae family (7 species) was the most frequently used plant family for pain relief. The most frequently used plant organ to relieve the pain was flower (25%), followed by the stem (22%) and leaves (19%). Conclusion: Given the high importance of medicinal plants in Shahrekord, the results of this study and additional scientific investigations can help produce more effective and less harmful drugs from medicinal plants. [GMJ.2019;8:e1593] DOI:10.31661/gmj.v8i0.1593

Keywords: Herbal Medicine; Sedatives; Ethnobotany; Shahrekord; Iran

Correspondence to:

Dr. Hassan Teimouri, Department of Anesthesiology, Lorestan University of Medical Sciences, Khorramabad, Iran

Telephone Number: 00989161613226

Email Address: hassan_teimouri@yahoo.com

GMJ.2019;8:e1593

www.gmj.ir

تصویر مرتبط

Figure 1. The map of Shahrekord city(southwest of Iran)

Table 1. The Scientific Names, Family, Persian Names, Used Organ(S), and Frequency of Use of Medicinal Plants Used as Analgesic in Shahrekord

Organ used

Frequency of use

Local name

Herbal family

Scientific name

Flower, Stem

44%

Mikhak

Myrtaceae 

Eugenia caryophylata

Root, stem

31%

Kharshotor

Fabaceae

Alhagi maurorum

Flower

31%

Babouneh

Asteraceae

Anthemis hyalina DC.

Leaf, flower

3%

Zarrin giah

Lamiaceae

Dracocephalum multicaule Montbr & Auch.

Aerial organs

13%

Marzanjoush

Lamiaceae

Origanum vulgare L.

Leaf

3%

Avishan

Lamiaceae

Thymus vulgaris

Flower, stem

3%

Gole raei

Hypericaceae

Hypericum scabrum L.

Leaf, stem

27%

Kharkhasak

Zygophyllaceae

Tribulus terrestris

Leaf, stem

2%

Mokhalaseh

Asteraceae

Tanacetum polycephalum (L.) Schultz-Bip.

Flower

6%

Gavzaban

Boraginaceae

Anchusa italyca Retz. (L.) DC.

Aerial organs

3%

Marzeh kouhi

Lamiaceae

Satureja bachtiarica Bung.

Leaf

3%

Naena

Lamiaceae 

Mentha sylvestris

Bulb

3%

Laleh vazhgoun

Liliaceae

Fritillaria imperialis L.

Aerial organs

24%

Ostokhodous

Lamiaceae

Lavandula angustifolia

Seed, leaf

2%

Bang daneh

Solanaceae

Hyoscyamus kotschyanus Pojark.

Flower

3%

Gole shaghaiegh

Papaveraceae

Papaver rhoeas

Aerial organs

3%

Boumadaran

Asteraceae

Achillea millefolium

Leaf

13%

Koma

Apiaceae

Ferula ovina Boiss.

Root, stem

2%

Zanjabil

Zingiberaceae

Zingiber officinale

Stem

13%

Darchin

Lauraceae

Cinnamomum verum

Seed

13%

Siah daneh

Ranunculaceae

Nigella sativa

Aerial organs

3%

Badranjbouyeh

 Lamiaceae

Melissa officinalis L

Flower, stem

3%

Sonbol atie

Caprifoliaceae

Valeriana officinalis

Figure 2. Plant families including species with analgesic effects

References

  1. Johnson MI, Elzahaf RA, Tashani OA. The prevalence of chronic pain in developing countries. Pain Manag. 2013; 3(2):83–6.
  2. Hoofwijk DM, Fiddelers AA, Peters ML, Stessel B, Kessels AG, Joosten EA. Prevalence and predictive factors of chronic postsurgical pain and poor global recovery 1 year after outpatient surgery. Clin J Pain. 2015; 31: 1017–1025.
  3. Thomson S. Failed back surgery syndromedefinition, epidemiology and demographics. Br J Pain. 2013; 7: 56–59.
  4. Fletcher D, Stamer UM, Pogatzki-Zahn E, Zaslansky R, Tanase NV, Perruchoud C. Chronic postsurgical pain in Europe: an observational study. Eur J Anaesthesiol. 2015; 32: 725–734.
  5. Tseli E, Boersma K, Stålnacke BM, Enthoven P, Gerdle B, Björn O. Äng, Wilhelmus A, Grooten JA. Prognostic Factors for Physical Functioning After Multidisciplinary Rehabilitation in Patients With Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis. Clin J Pain. 2019; 35(2): 148–173.
  6. Leadley RM, Armstrong N, Reid KJ, Allen A, Misso KV, Kleijnen J. Healthy aging in relation to chronic pain and quality of life in Europe. Pain Pract. 2014; 14: 547–558.
  7. Wallwork RS, Chipidza FE, Stern TA. Obstacles to the prescription and use of opioids. Prim Care Comp CNS Disord. 2016; 181:10.4088.
  8. Schmidtko A, Angioni C, Kuczka K, Schmidt H, Geisslinger G. Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia. Pain. 2009;147:116–121.
  9. Gil JS. Animal models of pain: progress and challenges. Nat Rev Neurosci. 2009; 10:283–294.
  10. Valizadeh R, Veisani Y, Delpisheh A, Kikhavani S, Sohrabnejad A. Major depression and psychiatric disorders in Iranian prisoners based on a clinical interview: A systematic review and meta-analysis. Shiraz E Med J. 2017; 18(6):e44979.
  11. Mohammadalizadeh-Charandabi S, Rezaei N, Hakimi S, Khatami SH, valizadeh R, Azadi A. Sleep disturbances and sexual function among men aged 45-75 years in an urban area of Iran. Sleep Sci. 2016; 9(1): 29–34.
  12. Valizadeh R, Sarokhani D, Sarokhani M, Sayehmiri K, Ostovar R, Angh P, Malekzadeh M. A study of prevalence of anxiety in Iran: Systematic review and meta-analysis. Der Pharma Chem. 2016; 8(21): 48-57.
  13. Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H. Medicinal plants: past history and future perspective. J HerbMed Pharmacol. 2018;1:1-7.
  14. Hosseini Z, Lorigooini Z, Rafieian-Kopaei M, Shirmardi HA, Solati K. A review of botany and pharmacological effect and chemical composition of Echinophora species growing in Iran. Pharmacog Rese. 2017; 9(4):305.
  15. Bahmani M, Khaksarian M, Rafieian-Kopaei M, Abbasi N. Overview of the therapeutic effects of Origanum vulgare and Hypericum perforatum based on Iran’s ethnopharmacological documents. J Clin Diag Res. 2018; 12(7): 1-4.
  16. Fathinezhad Z, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M. Depression and treatment with effective herbs. Curr Pharm Des. 2019 Apr 1.
  17. Nazarian-Samani Z, Sewell RD, Lorigooini Z, Rafieian-Kopaei M. Medicinal plants with multiple effects on diabetes mellitus and its complications: A Systematic review. Current Diab Reports. 2018 1; 18(10): 72.
  18. Bahmani M, Taherikalani M, Khaksarian M, Rafieian-Kopaei M, Ashrafi B, Nazer M.The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus. Future Sci OA. 2019 ;31:5(3):FSO371.
  19. Moradi F, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M. Immunosuppression-lipid Metabolism Interplay and Medicinal Plants in Atherosclerosis: A Review. Curr Pharm Des. 2018; 24:1-5.
  20. Nazer MR, Abbaszadeh S, Anbari K, Shams M. A review of the most important medicinal herbs affecting giardiasis. J HerbMed Pharmacol. 2019; 8(2):78-84.
  21. Ghanadi K, Hasanvand A, Abbaszadeh S, Heidari-Soureshjani S, Suhan T. Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy. Plant Sci Today. 2019; 6(2): 114-122.
  22. Shokri Z, Khoshbin M, Koohpayeh A, Abbasi N, Bahmani F, Rafieian-Kopaei, M, Beyranvand F. Thyroid diseases: Pathophysiology and new hopes in treatment with medicinal plants and natural antioxidants. Int J Green Pharmacy. 2018; 12(3): 473-482.
  23. Abbasi N, Mohammadpour S, Karimi E, Aidy A, Karimi P, Azizi M, Asadollahi K. Protective effects of smyrnium cordifolium boiss essential oil on pentylenetetrazol-induced seizures in mice: Involvement of benzodiazepine and opioid antagonists. J Biological Regulators Homeostatic Agents. 2017; 31(3):683-689.
  24. Pirzad-Jahromi G, Imani E, Nasehi M, Shahriari A. Effect of Achillea millefolium aqueous extract on memory deficit and anxiety caused by stroke in ovariectomized rats. J HerbMed Pharmacol. 2019; 8(2):153-159.
  25. Alami-Rostami S, Rafieirad M. The effect of hydro-alcoholic Ferulago angulata extract on locomotor activity and anxiety caused by hypoperfusion ischemia in adult male rats. J HerbMed Pharmacol. 2018;7(1):51-55.
  26. Kravchenko I, Eberle L, Nesterkina M, Kobernik A. Pharmacotherapy of inflammatory process by ginger extract (Zingiber officinale) ointment. J HerbMed Pharmacol. 2019;8(2):101-107..
  27. Torki A, Khalaji-Pirbalouty V, Lorigooini Z, Rafieian-Kopaei M, Sadeghimanesh A, Rabiei Z. Anchusa italica extract: phytochemical and neuroprotective evaluation on global cerebral ischemia and reperfusion. Brazilian J Pharmac Sci. 2018; 54(1): 3-7.
  28. Rahimi-Madiseh M, Heidarian E, Kheiri S, Rafieian-Kopaei M. Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. Biomed Pharmacoth. 2017; 86: 363-7.
  29. Kazemi S, Shirzad H, Rafieian-Kopaei M. Recent Findings in Molecular Basis of Inflammation and Anti-inflammatory Plants. Curr Pharm Des. 2018; 24(14):1551-62.
  30. Nejad ASM, Bahmani M, Shah NA, Shah SA, Rafieian-Kopaei M. Beliefs of herbal therapies of the community of the Ilam city of Ilam province, Iran. J Pharmacy Pharmacog Res. 2018; 6(4):299-317.
  31. Ghaderi H, Rafieian M, Nezhad HR. Effect of hydroalcoholic Cinnamomum zeylanicum extract on reserpine-induced depression symptoms in mice. Pharmacophore. 2018; 9(2):35-44.
  32. Bahmani M, Sarrafchi A, Shirzad H, Asgari S, Rafieian-Kopaei M. Cardiovascular Toxicity of Cyclooxygenase Inhibitors and Promising Natural Substitutes. Curr Pharm Des. 2017; 23(6):952-60.
  33. Heidari MR, Zahedi MJ and Rezvani H: Analgesic effect of Iavandula officinalis and histopatological studies in mice: Scientific-Research J Shahed Uni. 2000; 30(7): 23-30.
  34. Miladi-Gorji H, Rashidi Pour A, Vafaei AA, Taherian AA: Opioid receptors role on anti-nociceptive effects of the aqueous extracts of Melissa Officinalis in mice: J Hormozgan Uni Med Sci. 2006;10(1) :28-23.
  35. Pahlavan Y, Sepehri GR, Afarinesh-Khaki MR, Sheibani V, EsmailPour-Bezenjani K, Pahlavan B. Intervention of Morphine and Naloxone on Analgesic Effects of Origanum vulgare Extract in Male Rat: J Ardabil Uni Med Sci. 2010, 11 (2): 142-134.
  36. Verdi J, Kamalinezhad M, Sabet-Kasaei M, Sharif SH. Analgesic effect of aqueous satureja hortensis l. seed extract in male rat. J Physiol Pharmacol. 2005; 8(2):163-168.
  37. Eidi AH, Rustaiyan M, Eidi M. Bahramian: Antinociception effects of ethanolic extract of Mentha piperita leaves in adult male mice. Iranian J Biol. 2010;23 (4): 613-621.
  38. Parvin N, Ansari Samani R, Shahinfard N, Reissi S, Alibabaie Z, A. Asgari A. Effect of alcoholic extract of Tanacetum parthenium on acute pain in rat. J Qazvin Uni Med Sci. 2012, 16 (1) :15-21
  39. Kiasalari Z, Khalili M, Ashrafi M. Anti-nociceptive effect of alcoholic extract of henbane seed on the different phases of estrous cycle of female Rats: J Gorgan Uni Med Sci. 2010; 11 (4):1-7.
  40. Dashti-Rahmatabadi M, Vahidi-Merjardi A, Pilavaran A, Farzan F. Antinociceptive Effect of Cinnamon Extract on Formalin Induced Pain in Rat. JSSU. 2009; 17 (2): 190-199.
  41. Khalili M, Kiasalari Z, Farhadi E, Agah M. Effects of alcoholic extract of Zingiber officinalis rhizome on acute and chronic inflammation and pain in rats. Koomesh. 2010; 12 (2):159-166.
  42. Heidari MR, Asadipour A, Ghayoor M. Evaluation of analgesic and ulcerogenic effect of Methanolic extract of Matricaria Chamomilla L. J Qazvin Uni Med Sci. 2002; 5 (4) :15 23.
  43. Asadi-Samani M, Rafieian-Kopaei M, Lorigooini Z, Shirzad H. A screening of anti-breast cancer effects and antioxidant activity of twenty medicinal plants gathered from Chaharmahal va Bakhtyari province, Iran. J Pharm Pharmacogn Res. 2019; 7(3): 213–222.
  44. Hosseinzadeh-Samani B, Lorigooini Z, Rostami S, Zareiforoush H, Behruzian M, Behruzian A. The simultaneous effect of electromagnetic and ultrasound treatments on Escherichia coli count in red grape juice. J HerbMed Pharmacol. 2018; 7(1):29-36.
  45. Farzan B, Abbaszadeh S, Basati G, Teimouri H. An overview of the most important medicinal plants effective on the strength of memory and mind in Iranian ethnobotany. J Pharm Pharmacogn Res. 2019; 7(3): 156–162.

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