Validity and Reliability of the Persian Version of Leeds Dyspepsia Questionnaire

  • Sepideh Batebi Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Abbas Masjedi Arani Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran http://orcid.org/0000-0001-5521-0257
  • Mahdi Jafari 1. Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Amir Sadeghi Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mohsen Saberi Isfeedvajani Medicine, Quran and Hadith Research Center & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  • Mohammad Hassan Davazdah Emami Department of Health Psychology, Isfahan University of Medical Science, Isfahan, Iran
DOI: https://doi.org/10.31661/gmj.v8i0.1609
Keywords: Dyspepsia, Surveys and Questionnaires, Reproducibility of Results, Gastrointestinal Diseases, ROC Curve, Sensitivity and Specificity, Gastroesophageal Reflux

Abstract

Background: It is essential in clinical care services to measure the symptoms of functional dyspepsia both in the primary examination and treatment outcomes. No valid assessment tool is already available for functional dyspepsia in Iran. The present study aimed at evaluating the reliability, validity, and responsiveness of the Leeds dyspepsia questionnaire (LDQ). Materials and Methods: The LDQ was completed by 67 subjects with no dyspepsia symptoms and 93 subjects with certain functional dyspepsia diagnosed via endoscopy by a gastroenterologist and other clinical assessments. After definite diagnosis of functional dyspepsia, the participants were assessed by the LDQ. The psychometric characteristics of the questionnaire were then documented to investigate its reliability, validity, and responsiveness. Results: The internal consistency of the LDQ ranged from 0.80 to 0.89 and its test-retest reproducibility was 0.96. The LDQ was significantly correlated with all domains of dyspepsia symptom severity index (DSSI) and also with some of the domains of gastrointestinal symptom rating scale (GSRS). The LDQ had a sensitivity of 90.3% with a great specificity and a very good predictive validity. Moreover, a significant responsiveness to changes was observed (P<0.05). Conclusion: The LDQ is a valid, reliable, reproducible, and self-rated instrument responsive to change, which can be used to measure the frequency and severity of functional dyspepsia symptoms in clinical trials. [GMJ.2019;8:e1609] 

Author Biography

Abbas Masjedi Arani, Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Assistant Prof. Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

References

Moayyedi P, et al. The Leeds Dyspepsia Questionnaire: a valid tool for measuring the presence and severity of dyspepsia. Aliment Pharmacol Ther. 1998;12(12): 1257-1262.

https://doi.org/10.1046/j.1365-2036.1998.00404.x

PMid:9882035

Rezaee tavirani M, et al. The Prevalence of Gastrointestinal Diseases in Patients with Dyspepsia who Referred to Gastrointestinal Clinics in Ilam during the Years 2010-2011. SJIMU. 2015; 22(7): 32-38.

Henke CJ, Levin TR, Henning JM, Potter LP. Work loss costs due to peptic ulcer disease and gastroesophageal reflux disease in a health maintenance organization. Am J Gastroenterol. 2000; 95(3): 788-792.

https://doi.org/10.1111/j.1572-0241.2000.01861.x

PMid:10710076

Faramarzi M, Azadfallah P, Book HE, Rasolzadeh Tabatabai K, Taherim H, Kashifard M. The effect of psychotherapy in improving physical and psychiatric symptoms in patients with functional dyspepsia. Iran J Psychiatry. 2015; 10(1): 43-49.

Faghihi Kashani AH, Kabir A, Basi A. Comparison of Frequency of Helicobacter Pylori Infection in Subgroup of Patients with Non-Ulcer Dyspepsia. RJMS. 2003; 9(31): 557-566.

Allescher H, Functional dyspepsia-a multicausal disease and its therapy. Phymed. 2006; 13: 2-11.

https://doi.org/10.1016/j.phymed.2006.05.001

PMid:16859904

Zargar Y, Dehghanizadeh Z, MehrabizadehHonarmand M, Kadkhodaei A. The effectiveness of stress management cognitive behavior on functional dyspepsia symptoms and quality of life in patients with functional dyspepsia. Govaresh. 2012; 17(3): 148-155.

Lee HJ, et al. Depressive mood and quality of life in functional gastrointestinal disorders: differences between functional dyspepsia, irritable bowel syndrome and overlap syndrome. Gen Hosp Psychiatry. 2010; 32(5): 499-502.

https://doi.org/10.1016/j.genhosppsych.2010.05.002

PMid:20851270

Brook RA, Kleinman NL, Choung RS, Melkonian AK, Smeeding JE, Talley NJ. Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin Gastroenterol Hepatol. 2010; 8(6): 498-503.

https://doi.org/10.1016/j.cgh.2010.03.003

PMid:20304102

Sheikhian MR, Meysami Bonab S, Jarahi L, Eshghi S. Validity and Reliability of Persian Translation of the Nepean Dyspepsia Index in Functional Dyspepsia in Iran. Govaresh. 2016; 21(4): 238-243.

Talley NJ, Verlinden M, Jones M, Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form. Aliment PharmTher. 2001; 15(2): 207-216.

https://doi.org/10.1046/j.1365-2036.2001.00900.x

PMid:11148439

Moayyedi P, Mason J, Clinical and economic consequences of dyspepsia in the community. Gut. 2002; 50(4): 410-412.

https://doi.org/10.1136/gut.50.suppl_4.iv10

PMid:11953338 PMCid:PMC1867687

Fraser A, Delaney BC, Ford AC, Qume M, Moayyedi P. The short-form leeds dyspepsia questionnaire validation study. Aliment Pharmacol Ther. 2007; 25(4): 477-486.

https://doi.org/10.1111/j.1365-2036.2006.03233.x

PMid:17270004

Schmulson MJ, Drossman DA. What is new in Rome IV. Neurogastroenterol Motil. 2017; 23(2): 151-163.

https://doi.org/10.5056/jnm16214

PMid:28274109 PMCid:PMC5383110

Mahadeva S, Chan WK, Mohazmi M, Sujarita R, Goh KL. Validation study of the Leeds Dyspepsia Questionnaire in a multi-ethnic Asian population. J Gastroenterol Hepatol. 2011; 26(11): 1669-1676.

https://doi.org/10.1111/j.1440-1746.2011.06806.x

PMid:21649731

Chiba N, Veldhuyzen van Zanten SJO, Sinclair P, Ferguson RA, Escobedo S, Grace E. Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment Helicobacter pylori positive (CADET-Hp) randomised controlled trial. BMJ. 2002; 324(7344): 1012-1019.

https://doi.org/10.1136/bmj.324.7344.1012

PMid:11976244 PMCid:PMC102778

Heading RC. Definitions of dyspepsia. Scand J Gastroenterol. 1991; 26(182): 1-6.

https://doi.org/10.3109/00365529109109529

PMid:1896823

Kuykendall DH, Rabeneck L, Campbell CJM, Wray NP. Dyspepsia: how should we measure it? J Clin Epidemiol. 1998; 51(2): 99-106.

https://doi.org/10.1016/S0895-4356(97)00245-X

Leidy NK, Farup C, Rentz AM, Ganoczy D, Koch KL. Patient-Based Assessment in Dyspepsia. Dig Dis Sci. 2000; 45(6): 1172-1179.

https://doi.org/10.1023/A:1005558204440

PMid:10877234

Revicki DA, Wood M, Wiklund I, Crawley J. Reliability and validity of the Gastrointestinal Symptom Rating Scale in patients with gastroesophageal reflux disease. Qual Life Res. 1997; 7(1): 75-83.

https://doi.org/10.1023/A:1008841022998

PMid:9481153

Mazaheri M, SadatKhoshouei M. Comparison between Psychometric Characteristics of Persian Version of the Gastrointestinal Symptoms Rating Scale in Functional Gastrointestinal Disorders and Normal Groups. Govaresh. 2012; 17(1): 18-24.

https://doi.org/10.5455/medarh.2012.66.28-32

PMid:22482339

Kulich KR, et al. Reliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia: a six-country study. Health Qual Life Outcomes. 2008; 6(1): 12-24.

https://doi.org/10.1186/1477-7525-6-12

PMid:18237386 PMCid:PMC2276197

HU WH, et al. The Hong Kong index of dyspepsia: a validated symptom severity questionnaire for patients with dyspepsia. J Gastroenterol Hepatol. 2002; 17(5): 545-551.

https://doi.org/10.1046/j.1440-1746.2002.02713.x

PMid:12084027

Published
2019-12-31
How to Cite
Batebi, S., Masjedi Arani, A., Jafari, M., Sadeghi, A., Saberi Isfeedvajani, M., & Davazdah Emami, M. H. (2019). Validity and Reliability of the Persian Version of Leeds Dyspepsia Questionnaire. Galen Medical Journal, 8, e1609. https://doi.org/10.31661/gmj.v8i0.1609
Issue
Vol. 8 (2019): 2019
Section
Original Article

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