Cover Image

Prevalence of Common Candida Species in Oral Lichen Planus Patients: A Cross-Sectional Study in South of Iran

Hooman Ebrahimi, Keyvan Pakshir, Sara Pourshahidi, Kamyar Zomorodian, Maryam Saki, Nasrin Saki, Maryam Valizadeh, Sina Kardeh

Background: Lichen Planus is a common mucocutaneous disease with unknown etiology. Immunodeficiency is a known predisposing factor to this disease. Oral Candidiasis which is an opportunistic fungal infection, commonly affects healthy and immune-compromised patients. Candida has different species bearing different treatments. In this study, researchers aimed to detect the frequency and colonization rate of Candida and its association with different factors such as lesion types of oral lichen Planus (OLP).Materials and Methods: Thirty seven untreated oral lichen Planus patients, attending the Clinical Department of Oral Medicine at Shiraz Dental School in 2011, were selected. Swab method and CHROMagar media were used to obtain samples incubated for 48 hours at 30 ºC. Fungal species were detected considering colony color changes.Results: In the culture test, approximately 80% of samples were positive of non-reticular type. About 40% of positive samples were of Candida non-albicans (C.Non-albicans) type. Among C. Non-albicans, 85% were non-reticular type among OLP patients. There was no significant statistical difference in prevalence of Candida albicans (C.albicans) and C. Non-albicans in OLP patients.Conclusion: Based on results, certain biotypes of Candida were not confirmed responsible for OLP patterns.[GMJ.2014;3(4):252-5]


Candida albicans; Lichen planus; Oral mucosa; Etiology; Prevalence; Biotype

ZENG X, XIONG C, WANG Z, JIANG L, HOU X, SHEN J, et al. Genotypic profiles and virulence attributes of Candida. APMIS : 2008; 116(4): p. 284–91.

Neville B, Dam D, Allen C, Bouquot J. Oral and maxillofacial pathology. 3rd ed.; 2009.

Shklar G. Lichen planus as an oral ulcerative disease. oral surg. 1972; 33(3): p. 376-388.

Voute A, De Jong W, Schulten E, Snow G, Van der Waal I. Possible premalignant character of oral lichen planus. J Oral Patho; Med. 1992; 21: p. 326-329.

Cheng S. Oral Lichen Planus. Hong Kong dermatology & venereology bulletin. 2002; 10(4): p. 170-172.

Katz R, Brahim J, Travis W. Oral squamous cell carcinoma arising in a patient with long-standing lichen planus. Oral Surg Oral Med Oral Pathol. 1990; 70: p. 282-285.

Obradovic R, Kesic L, Mihailovic D, Radicevic G. Malignant transformation of oral lichen planus, a case report. West Indian Med J. 2009; 58(5): p. 490-2.

Masaki M, Sato T, Sugawara Y, Sasano T, Takahashi N. Detection and identification of non-Candida albicans species. Microbiol Immunol. 2011; 55: p. 66–70.

Kaugars G, Svirsky J. An update on the dysplastic/carcinomatous transformation of oral lichen planus. Oral Med J. 1982; 37(3): p. 75-79.

Mehdipour M, Taghavi Zenouz A, Hekmatfar S, Adibpour M, Bahramian A, Khorshidi R. Prevalence of Candida Species in Erosive Oral Lichen Planus. J Dent Res Dent Clin Dent Prospect. 2010; 4(1): p. 14-16.

Zeng X, Hou X, Wang Z, Jiang L, Xiong C, Zhou M, et al. Carriage rate and virulence attributes of oral Candida albicans isolates from patients with oral lichen planus: a study in an ethnic Chinese cohort. Mycoses. 2009; 52(2): p. 161–165.

Akpan A, Morgan R. Oral candidiasis. Postgrad Med J. 2002; 78: p. 455-459.

Merz W, Hay R. Medical mycology. 10th ed. USA: Edward Arnold LTC, 2005.

Zeng X, Hou X, Wang Z, Jiang L, Xiong C, Zhou M, et al. Carriage rate and virulence attributes of oral Candida albicans isolates. Mycoses. 2008; 52: 161-165.

Kragelund C, Kieffer-Kristensen L, Reibel J, Bennett EP. Oral candidosis in lichen planus: the diagnostic approach is of major therapeutic importance. Clin Oral Investig. 2013 ;17(3):957-65

LI Jy, SUN Hy, ZHANG Qq. Antifungal susceptibility test of genotypes of Candida albicans from patients with atrophie or erosive oral lichen. Shanghai Kou Qiang Yi Xue. 2011 Jun;20(3):300-3.

Refbacks

  • There are currently no refbacks.