
Wound Healing Potential of Crocin and Safranal, Main Saffron (Crocus sativus L.), the Active Constituents in Excision Wound Model in Rats
Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol. 2007;25(1):9-18.
https://doi.org/10.1016/j.clindermatol.2006.09.007
PMid:17276196
Bradley M, Cullum N, Nelson EA, Petticrew M, Sheldon T, Torgerson D. Systematic reviews of wound care management: (2). Dressings and topical agents used in the healing of chronic wounds. Health Technol Assess. 1999;3(17 Pt 2):1-35
https://doi.org/10.3310/hta3172
Biswas TK, Mukherjee B. Plant medicines of Indian origin for wound healing activity: a review. Int J Low Extrem Wounds. 2003;2(1):25-39.
https://doi.org/10.1177/1534734603002001006
PMid:15866825
Hosseinzadeh H, Nassiri-Asl M. Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. Phytother Res. 2013;27(4):475-83.
https://doi.org/10.1002/ptr.4784
PMid:22815242
Zeka K, Ruparelia KC, Sansone C, Macchiarelli G, Continenza MA, Arroo RR. New hydrogels enriched with antioxidants from saffron crocus can find applications in wound treatment and/or beautification. Skin Pharmacol Physiol. 2018;31(2):95-8.
https://doi.org/10.1159/000486135
PMid:29393263
Verjee S, Garo E, Pelaez S, Fertig O, Hamburger M, Butterweck V. Saffron flower extract promotes scratch wound closure of keratinocytes and enhances VEGF production. Planta Med. 2017;83(14/15):1176-83.
https://doi.org/10.1055/s-0043-109002
PMid:28427103
Khorasani G, Hosseinimehr SJ, Zamani P, Ghasemi M, Ahmadi A. The effect of saffron (Crocus sativus) extract for healing of second-degree burn wounds in rats. Keio J Mede. 2008;57(4):190-5.
https://doi.org/10.2302/kjm.57.190
PMid:19110531
Alemzadeh E, Oryan A. Effectiveness of a Crocus sativus extract on burn wounds in rats. Planta Med. 2018;84(16):1191-200.
https://doi.org/10.1055/a-0631-3620
PMid:29791931
Directive E. 63/EU (2010). Legislation for the protection of animals used for scientific purposes. 2016.(Accessed June 1, 2020, at https://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm)
Niazi M, Mehrabani M, Namazi MR, Salmanpour M, Heydari M, Karami MM, Parvizi MM, Fatemi I, Mehrbani M. Efficacy of a topical formulation of henna (Lawsonia inermis L.) in contact dermatitis in patients using prosthesis: A double-blind randomized placebo-controlled clinical trial. Complement Ther Med. 2020;49(1):102316.
https://doi.org/10.1016/j.ctim.2020.102316
PMid:32147071
Fischer AH, Jacobson KA, Rose J, Zeller R. Hematoxylin and eosin staining of tissue and cell sections. Cold Spring Harb Protoc. 2008;2008(5):pdb. prot4986.
https://doi.org/10.1101/pdb.prot4986
PMid:21356829
Hashempur MH, Hashempour MM, Mosavat SH, Heydari M. Rhazes-his life and contributions to the field of dermatology. JAMA dermatol. 2017;153(1):70.
https://doi.org/10.1001/jamadermatol.2016.0144
PMid:28114524
Atarzadeh F, Heydari M, Sanaye MR, Amin G. Avicenna-A pioneer in dermatology. JAMA dermatol. 2016;152(11):1257.
https://doi.org/10.1001/jamadermatol.2016.0026
PMid:27829112
Ahmed S, Hasan MM, Heydari M, Rauf A, Bawazeer S, Abu-Izneid T, Rebezov M, Shariati MA, Daglia M, Rengasamy KR. Therapeutic potentials of crocin in medication of neurological disorders. Food Chem Toxicol. 2020;145(1):111739.
https://doi.org/10.1016/j.fct.2020.111739
PMid:32916219
Hosseinzadeh H, Ziaee T, Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine. 2008;15(6-7):491-5.
https://doi.org/10.1016/j.phymed.2007.09.020
PMid:17962007
Bukhari SI, Pattnaik B, Rayees S, Kaul S, Dhar MK. Safranal of Crocus sativus L. inhibits inducible nitric oxide synthase and attenuates asthma in a mouse model of asthma. Phytother Res. 2015;29(4):617-27.
https://doi.org/10.1002/ptr.5315
PMid:25756352
Samarghandian S, Shabestari MM. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol.. 2013;29(3):177.
https://doi.org/10.4103/0970-1591.117278
PMid:24082436 PMCid:PMC3783695
Refbacks
- There are currently no refbacks.