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Effect of Probiotics on Allergic Rhinitis: A Randomized, Controlled, Clinical Trial

Mahnaz Sadeghi-Shabestari, Yalda Jabbari Moghaddam, Hasan Rezapoor, Mojataba Sohrabpour

Background: Allergic rhinitis (AR) is one of the most common diseases in the world and affects about 10-50% of the general population. Probiotics are live microorganisms that help the normal state of the intestine, and if prescribed correctly, they can stimulate the mucosal immune system to prevent inflammatory symptoms of allergy and atopy. The present study aims to investigate the role of probiotics in the treatment of AR when added to standard therapy as adjuvant agents. Materials and Methods: In this clinical trial study, 28 patients older than 15 years with AR randomly divided into probiotics and control groups. The probiotics group received standard therapy for AR accompanied by probiotic capsules every 12 hours for eight weeks, whereas the control group received standard therapy for AR with placebo capsules as the same protocol. Data were analyzed using SPSS Version 23 (IBM Corporation, Armonk, NY, USA) and, the P-value less than 0.05 was considered statistically significant. Results: In the probiotics group, 14.3% of patients had sneezing at the baseline, which significantly decreased to 4.6% (P<0.01). Also, the necessity for nasal and oral corticosteroids after treatment with probiotics in the probiotics group was less than the control group (P<0.01). Although cough, nasal discharge, conchae hypertrophy, and night sleep disorders reduced after treatment with probiotics, this reduction was not statistically significant between the two groups. Conclusion: Based on the results of this clinical trial, the use of probiotics had no significant effect on the outcome of patients with AR. [GMJ.2020;9:e1918] 

Probiotics; Allergic Rhinitis; Adult

Mårtensson A, Abolhalaj M, Lindstedt M, Mårtensson A, Olofsson TC, Vásquez A, et al. Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: a randomized controlled trial. Laryngoscope Investig Otolaryngol. 2017;2(6):410-6.

https://doi.org/10.1002/lio2.93

PMid:29299516 PMCid:PMC5743165

Lin W-Y, Fu L-S, Lin H-K, Shen C-Y, Chen Y-J. Evaluation of the effect of Lactobacillus paracasei (HF. A00232) in children (6-13 years old) with perennial allergic rhinitis: a 12-week, double-blind, randomized, placebo-controlled study. Pediatr Neonatol. 2014;55(3):181-8.

https://doi.org/10.1016/j.pedneo.2013.10.001

PMid:24269033

Peng Y, Li A, Yu L, Qin G. The role of probiotics in prevention and treatment for patients with allergic rhinitis: A systematic review. Am J Rhinol Allergy. 2015;29(4):292-8.

https://doi.org/10.2500/ajra.2015.29.4192

PMid:26163249

Zajac AE, Adams AS, Turner JH, editors. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis. International forum of allergy & rhinology; 2015: Wiley Online Library.

https://doi.org/10.1002/alr.21492

PMid:25899251 PMCid:PMC4725706

Jan R-H, Chen C-J, Chen L-K, Wen S-H, Lin T-Y. Is the effect of probiotics on allergic rhinitis confined to Dermatophagoides farinae, Dermatophagoides pteronyssinus, or dust-sensitive children? A randomized prospective double-blind controlled trial. Ci Ji Yi Xue Za Zhi. 2011;23(2):51-4.

https://doi.org/10.1016/j.tcmj.2011.05.003

May JR, Dolen WK. Management of allergic rhinitis: a review for the community pharmacist. Clinical therapeutics. 2017;39(12):2410-9.

https://doi.org/10.1016/j.clinthera.2017.10.006

PMid:29079387

Anand S, Mande SS. Diet, microbiota and gut-lung connection. Front Microbiol. 2018;9:2147.

https://doi.org/10.3389/fmicb.2018.02147

PMid:30283410 PMCid:PMC6156521

Ipci K, Altıntoprak N, Muluk NB, Senturk M, Cingi C. The possible mechanisms of the human microbiome in allergic diseases. Eur Arch Otorhinolaryngol . 2017;274(2):617-26.

https://doi.org/10.1007/s00405-016-4058-6

PMid:27115907

Xiao JZ, Kondo S, Yanagisawa N, Takahashi N, Odamaki T, Iwabuchi N, et al. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin Exp Allergy. 2006;36(11):1425-35.

https://doi.org/10.1111/j.1365-2222.2006.02575.x

PMid:17083353

Nishimura I, Igarashi T, Enomoto T, Dake Y, Okuno Y, Obata A. Clinical efficacy of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi for perennial allergic rhinitis. Allergol Int. 2009;58(2):179-85.

https://doi.org/10.2332/allergolint.O-08-548

PMid:19240374

Güvenç IA, Muluk NB, Mutlu FŞ, Eşki E, Altıntoprak N, Oktemer T, et al. Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis. Am J Rhinol Allergy. 2016;30(5):e157-e75.

https://doi.org/10.2500/ajra.2016.30.4354

PMid:27442711

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