The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines

  • Maryam Ostovan 1. Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Hossein Anbardar 2. Department of Pathology, Shiraz University of medical sciences, Shiraz, Iran
  • hajar khazraei 3. Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Seyyed Mohammad bagher Fazljou 1. Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Zahra Khodabandeh 4. Stem cell Technology Research Center, Shiraz University of Medical Science, Shiraz, Iran
  • Seyedeh Azra Shamsdin 5. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mostafa Araj Khodaei 1. Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammadali Torbati 6. Department of Traditional Pharmacy, School of Traditional medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords: Mastic; Rats; Sesame Oil; Liver; Kidney


Background: Vegetable oils recently have been evaluated in many tissues. Pistacia lentiscus (mastic) of the Anacardiaceae family and Sesamum indicum (sesame) of the Pedaliaceae family are conventionally used in the management of gastrointestinal, lung, and skin illnesses. This assay attempts to determine if the oral usage of mastic and sesame oils has any short-term toxic effects in vivo on the rat and evaluate the human anticancer effect in vitro.  Materials and Methods: Twenty-one male Sprague-Dewley rats were assigned to three groups randomly: (A) control, (B) mastic oil (400 mg/kg), and (C) sesame oil (2cc/kg). The effects of these oils were investigated by determining histopathological and stereological parameters after six days, and the anticancer effects were evaluated on SW48, HepG2 human cell lines. Results: A mild chronic interstitial inflammation was seen in just one kidney of mastic oil group (B) and the other oneswere normal. In the sesame oil group (C), mild chronic interstitial inflammation was seen in six kidneys. In the liver samples of both groups, there were no specific pathological findings. Different concentrations of mastic oil (0.1%-5%) reduced the cell viability of SW48, HepG2, HEK293t, and human fat cells. Conclusion: Mastic and sesame oils have some side-effects on the kidney and might not be safe at high doses in rats. Sesame oil did not have any toxic effect on HepG2 and HEK293t human cancer cells. Mastic oil treatment has inhibited specific SW48 cells, so this oil seems to be a good adjuvant to chemotherapy in colon treatments.[GMJ.2020;9:e2001]


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How to Cite
Ostovan, M., Anbardar, M. H., khazraei, hajar, Fazljou, S. M. bagher, Khodabandeh, Z., Shamsdin, S. A., Araj Khodaei, M., & Torbati, M. (2020). The Short-Term Effects of Pistacia Lentiscus Oil and Sesame Oil on Liver and Kidney Pathology of Rats and Human Cancer Cell Lines. Galen Medical Journal, 9, e2001.
Original Article