Changes in Serum Alkaline Phosphatase, Calcium, and Parathyroid Hormone with Different Doses of Iodine Therapy

Changes in Serum ALP, Ca, and PTH Levels among Patients with Iodine Therapy

  • Mohammad Mehdi Movahedi Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Ionizing and Non- Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
  • Gholam Reza Karimaghaei School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ahmad Noori Novin Iran Specialized Dermatology Clinic, Shiraz, Iran
  • Mohammad Atefi Ionizing and Non- Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran; Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Tahereh Mahmoudi Department of Medical Physics and Biomedical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Farshid Gheisari Ionizing and Non- Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran; The Hospital for Sick Children, Toronto, Canada
Keywords: Nuclear Medicine, Thyroid Cancer, Radioactive Iodine, Alkaline Phosphatase, Serum Calcium, Parathyroid Hormone

Abstract

Background: Despite the benefits of radioactive iodine (RAI) therapy as an adjunctive treatment for thyroid cancer, it can be associated with several side effects. The main purpose of this study was to determine the changes in serum alkaline phosphatase (ALP), calcium (Ca), and parathyroid hormone (PTH) at different doses of RAI therapy among patients who were referred to the nuclear medicine department of Namazi Hospital, Shiraz. Materials and Methods: This cross-sectional study was conducted on 60 patients with papillary thyroid cancer who underwent RAI therapy at different doses of 100, 150, and 200 mCi. The ALP, Ca, and PTH levels of patients were measured before and 60 days after RAI therapy. Results: Our study revealed that RAI therapy at all doses significantly increased ALP level in comparison with baseline amounts (P≤0.05). However, changes in PTH and Ca levels were not significant among patients who received different doses of RAI (P˃0.05). Conclusion: RAI therapy could affect important hormones and enzymes such as ALP and PTH. This issue can be considered in diagnostic and therapeutic prescriptions of RAI for the treatment of thyroid cancer.

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Published
2022-10-18
How to Cite
Movahedi, M. M., Karimaghaei, G. R., Noori, A., Atefi, M., Mahmoudi, T., & Gheisari, F. (2022). Changes in Serum Alkaline Phosphatase, Calcium, and Parathyroid Hormone with Different Doses of Iodine Therapy : Changes in Serum ALP, Ca, and PTH Levels among Patients with Iodine Therapy. Galen Medical Journal, 11, e2397. https://doi.org/10.31661/gmj.v11i.2397
Section
Short Communication