The Effects of Aroma on Apnea Attacks and Oxygen Saturation Among Preterm Infants: A Systematic Review and Meta-Analysis

  • Sanaz Rustaee Department of Nursing Internal Surgery, School of Nursing, Fasa University of Medical Sciences, Fasa, Iran
  • Rafat Rezapour-Nasrabad Department of Psychiatric Nursing and Management, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Masumeh Ghazanfarpour Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • Saeedeh Piri Department of Nursing, Lorestan University of Medical Science, Shahid Madani Hospital, Khorramabad, Iran
  • Seyedeh Fatemeh Moosavi Moqaddam Department of Nursing, School of Nursing, Jahrom University of Medical Sciences, Jahrom, Iran
  • Arian Behdarvandi Department of Biology, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  • Fatemeh Kafami Ladani Department of Nursing, Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran
  • Ahmad Rahmah Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
  • Maryam Mirzaei Department of Obstetrics and Gynecology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
Keywords: Premature, Aromatherapy, Herbal, Infants, Oxygen Saturation


Researchers and clinicians need to be aware of procedures that are more adaptable to new and different environments in premature infants; therefore, it is important to conduct a comprehensive review of the effect of aromatherapy on apnea attacks and oxygen saturation (SpO2) in premature newborns. In this review, databases such as PubMed, Scopus, Web of Science, and Cochrane Library were systematically searched without language and time limitations up to November 1, 2022. Initially, 153 studies were founded, and after duplicate removal, title as well as full-text review, seven studies were enrolled in the final analysis. Studies indicated that aromatherapy with Rosa damascena, vanilla, and breast milk odors could significantly reduce apneas in preterm infants and improve SpO2 levels. Hence, aromatherapy could consider as an effective adjuvant treatment for the reduction of apnea attacks among preterm infants.


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How to Cite
Rustaee , S., Rezapour-Nasrabad , R., Ghazanfarpour , M., Piri , S., Moosavi Moqaddam , S. F., Behdarvandi , A., Kafami Ladani , F., Rahmah, A., & Mirzaei, M. (2023). The Effects of Aroma on Apnea Attacks and Oxygen Saturation Among Preterm Infants: A Systematic Review and Meta-Analysis. Galen Medical Journal, 12, e2846.
Review Article