The Effects of Aroma on Apnea Attacks and Oxygen Saturation Among Preterm Infants: A Systematic Review and Meta-Analysis
AbstractResearchers and clinicians need to be aware of procedures that are more adaptable to new and different environments in premature infants; therefore, it is important to conduct a comprehensive review of the effect of aromatherapy on apnea attacks and oxygen saturation (SpO2) in premature newborns. In this review, databases such as PubMed, Scopus, Web of Science, and Cochrane Library were systematically searched without language and time limitations up to November 1, 2022. Initially, 153 studies were founded, and after duplicate removal, title as well as full-text review, seven studies were enrolled in the final analysis. Studies indicated that aromatherapy with Rosa damascena, vanilla, and breast milk odors could significantly reduce apneas in preterm infants and improve SpO2 levels. Hence, aromatherapy could consider as an effective adjuvant treatment for the reduction of apnea attacks among preterm infants.
Mohammadi F, Tabatabaei HS, Mozafari F, Gillespie M. Caregivers' perception of women's dignity in the delivery room: a qualitative study. Nurs Ethics. 2020;27(1):116-26.
Mohammadi F, Oshvandi K. Male nursing students' perception of dignity in neonatal intensive care units. Nurs Ethics. 2020;27(2):381-9.
Mohammadi F, Kiani A, Gholamzadeh S, Asadi Noghabi F, Sadeghi T. The factors affecting successful breast-feeding (SBF). Iranian Journal of Neonatology. 2018;9(2):73-82.
Mohammadi F, Rakhshan M, Molazem Z, Zareh N, Gillespie M. Development of parental competence scale in parents of children with autism. J Pediatr Nurs. 2020;50:e77-e84.
Tehranineshat B, Mohammadi F, Tazangi RM, Sohrabpour M, Parviniannasab AM, Bijani M. A study of the relationship among burned patients' resilience and self-efficacy and their quality of life. Patient Prefer Adherence. 2020;14:1361-9.
Wren AA, Ross AC, D'Souza G, Almgren C, Feinstein A, Marshall A, et al. Multidisciplinary pain management for pediatric patients with acute and chronic pain: a foundational treatment approach when prescribing opioids. Children (Basel). 2019; 6(2): 33.
Bucsea O, Riddell RP. Non-pharmacological pain management in the neonatal intensive care unit: Managing neonatal pain without drugs. Semin Fetal Neonatal Med. 2019;24(4):101017.
Mohammadi F, Farjam M, Gholampour Y, Sohrabpour M, Oshvandi K, Bijani M. Caregivers' perception of the caring challenges in coronavirus crisis (COVID-19): a qualitative study. BMC Nurs. 2021;20(1):102.
Vahdatpour B, Haghighat S, Sadri L, Taghian M, Sadri S. Effects of Transfer Energy Capacitive and Resistive On Musculoskeletal Pain: A Systematic Review and Meta-Analysis. Galen Medical Journal. 2022 Nov 15;11:e2407-.
Mohammadi F, Tehranineshat B, Bijani M, Khaleghi AA. Management of COVID-19-related challenges faced by EMS personnel: a qualitative study. BMC Emerg Med. 2021;21(1):95.
Neshat H, Jebreili M, Seyyedrasouli A, Ghojazade M, Hosseini MB, Hamishehkar H. Effects of Breast Milk and Vanilla Odors on Premature Neonate's Heart Rate and Blood Oxygen Saturation During and After Venipuncture. Pediatr Neonatol. 2016;57(3):225-31.
Soleymani B, Hemmati F, Pishva N. Evaluation of the Effect of Oral Carnitine Supplementation on Apnea of prematurity in Premature Neonates in Hospitals Affiliated to Shiraz University of Medical Sciences. J Biochem Tech. 2019;(2): 55-8.
Eichenwald EC. Apnea of prematurity. Pediatrics. 2016;137(1):e20153757.
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, et al. Caffeine therapy for apnea of prematurity. N Engl J Med. 2006;354(20):2112-21.
Edraki M, Pourpulad H, Kargar M, Pishva N, Zare N, Montaseri H. Olfactory stimulation by vanillin prevents apnea in premature newborn infants. Iran J Pediatr. 2013;23(3):261-8.
Henderson-Smart DJ, Steer PA. Methylxanthine treatment for apnea in preterm infants. Cochrane Database Syst Rev. 2001;(3):CD000140.
Pillekamp F, Hermann C, Keller T, Von Gontard A, Kribs A, Roth B. Factors influencing apnea and bradycardia of prematurity-implications for neurodevelopment. Neonatology. 2007;91(3):155-61.
Marlier L, Gaugler C, Messer J. Olfactory stimulation prevents apnea in premature newborns. Pediatrics. 2005;115(1):83-8.
Kanbur BN, Balci S. Impact of the odors of vanilla extract and breast milk on the frequency of apnea in preterm neonates. Jpn J Nurs Sci. 2020;17(1):e12271.
Beker F, Opie G, Noble E, Jiang Y, Bloomfield FH. Smell and taste to improve nutrition in very preterm infants: a randomized controlled pilot trial. Neonatology. 2017;111(3):260-6.
Yaghoubi S, Salmani N, Dehghani K, DavoodiZadehJolgeh H. Investigating effect of olfactory stimulation by vanilla on the rate of apnea attacks in neonates with apnea of prematurity: A randomized clinical trial. Int J Pediatr. 2017;5(12):6221-9.
Piri SM, Ghodsi Z, Shool S, Anjomshoa A, Azarhomayoun A, Jangholi E, et al. Macrophage migration inhibitory factor as a therapeutic target after traumatic spinal cord injury: a systematic review. Eur Spine J. 2021;30(6):1474-1494.
Park YA, Im YJ. The effects of a continuous olfactory stimulation using breast milk (COSB) on behavioral state and physiological responses in Korean premature infants. J Pediatr Nurs. 2020;53:e114-e20.
Alemdar DK, İnal S. The effect of individualized developmental care practices in preterm infants. Complement Med Res. 2020;27(2):97-104.
Aghagoli S, Salimi A, Salimi M, Ghazavi Z, Marofi M, Mohammadbeigi A. Aromatherapy with rosa damascenes in apnea, bradycardia and Spo2 of preterm infants; a randomized clinical trial. Int J Pediatr. 2016;4(6):1911-8.
Ataei Nakhaei A, Javid A, Marefat M, Chaichy Z, Alshahrestani A, Nazarpour P. Is Aromatherapy Effective for Apnea in Preterm Infants? A Systematic Review Int J Pediatr. 2019;7(7):9741-7.
Gambari R. Predictive Analyses of Biological Effects of Natural Products: From Plant Extracts to Biomolecular Laboratory and Computer Modeling. Evid Based Complement Alternat Med. 2011; 2011: 383290.
Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczok T. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774. 2 macrophages Pharmacol Rep. 2005;57(3):390-4.
Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological Effects of Rosa Damascena. Iran J Basic Med Sci. 2011;14(4):295-307.
Marofi M, Sirousfard M, Moeini M, Ghanadi A. Evaluation of the effect of aromatherapy with Rosa damascena Mill on postoperative pain intensity in hospitalized children in selected hospitals affiliated to Isfahan University of Medical Sciences in 2013: A randomized clinical trial. Iran J Nurs Midwifery Res. 2015;20(2):247-54.
Hongratanaworakit T. Relaxing effect of rose oil on humans. Nat Prod Commun. 2009;4(2):291-6.
Copyright (c) 2023 Galen Medical Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).