Intensive Insulin Therapy Reduces Infections in Patients on Parenteral Nutrition: A Randomized Clinical Trial

  • Seyedeh Neda Mousavi Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  • Abdolreza Norouzy Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Nematy Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohamad Safarian Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  • Fariborz Samini Department of Neurosurgery, Research Center of Orthopedic Surgery of ShahidKamyab Hospital, Mashhad, Iran
  • Ali Birjandinejad Department of Neurosurgery, Research Center of Orthopedic Surgery of ShahidKamyab Hospital, Mashhad, Iran
  • Seyed Javad Purafzalifiruzabadi Medical Student, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords: Pathogen growth, Parenteral nutrition, Intensive insulin therapy, Hypoglycemia

Abstract

Introduction: Hyperglycemia is a common problem encountered in hospitalized patients, especially in critically ill patients due to stress and using parenteral nutrition. Uncontrolled hyperglycemia may be associated with increased infection risk. The principal benefit of intensive insulin therapy is a decrease in infection-related complications and mortality. The aim of this study was the assessment of IIT effect on pathogen growth in ICU patients. Materials and Methods: We conducted a randomized controlled trial study where patients with brain trauma in grade 2 and 3 that received at least 50% of nutritional needs from parenteral nutrition. They randomly assigned to receive IIT or conventional glucose control. Pathogen growth, mortality, survival, APACHE II score, duration of hospital stay was assessed. Results: Of 29 patients randomized, 26 patients completed the study. Survival duration, ventilator dependency and pathogen growth was improved in tight control group but not significant between two groups due to low sample size. Conclusion: In our study, IIT reduced pathogen growth without hypoglycemic episodes in head trauma patients.[GMJ. 2012;1(1):2-7]
Published
2012-10-04
How to Cite
Mousavi, S. N., Norouzy, A., Nematy, M., Safarian, M., Samini, F., Birjandinejad, A., & Purafzalifiruzabadi, S. J. (2012). Intensive Insulin Therapy Reduces Infections in Patients on Parenteral Nutrition: A Randomized Clinical Trial. Galen Medical Journal, 1(1), 2-7. https://doi.org/10.31661/gmj.v1i1.3
Section
Original Article