Intensive Insulin Therapy Reduces Infections in Patients on Parenteral Nutrition: A Randomized Clinical Trial
Keywords:
Pathogen growth, Parenteral nutrition, Intensive insulin therapy, Hypoglycemia
Abstract
Introduction: Hyperglycemia is a common problem encountered in hospitalized patients, especially in critically ill patients due to stress and using parenteral nutrition. Uncontrolled hyperglycemia may be associated with increased infection risk. The principal benefit of intensive insulin therapy is a decrease in infection-related complications and mortality. The aim of this study was the assessment of IIT effect on pathogen growth in ICU patients. Materials and Methods: We conducted a randomized controlled trial study where patients with brain trauma in grade 2 and 3 that received at least 50% of nutritional needs from parenteral nutrition. They randomly assigned to receive IIT or conventional glucose control. Pathogen growth, mortality, survival, APACHE II score, duration of hospital stay was assessed. Results: Of 29 patients randomized, 26 patients completed the study. Survival duration, ventilator dependency and pathogen growth was improved in tight control group but not significant between two groups due to low sample size. Conclusion: In our study, IIT reduced pathogen growth without hypoglycemic episodes in head trauma patients.[GMJ. 2012;1(1):2-7]
Published
2012-10-04
How to Cite
Mousavi, S. N., Norouzy, A., Nematy, M., Safarian, M., Samini, F., Birjandinejad, A., & Purafzalifiruzabadi, S. J. (2012). Intensive Insulin Therapy Reduces Infections in Patients on Parenteral Nutrition: A Randomized Clinical Trial. Galen Medical Journal, 1(1), 2-7. https://doi.org/10.31661/gmj.v1i1.3
Section
Original Article
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).