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Lipid Peroxidation Product and Glutathione Levels in Patients with Coronary Heart Disease Before and After Surgery

Rahman Khansha, Behnoosh Miladpour, Zohreh Mostafavi-Pour, Fatemeh Zal

Background: It has been reported that ischemia-reperfusion is associated with augmentation of oxidative stress and its specific and sensitive markers. Oxidative stress may cause atrial fibrillation (AF) which is a common consequence after cardiac surgery. Dietary supplementation with antioxidants might lower the incidence of AF following coronary artery bypass graft (CABG) surgery. Materials and Methods: Fifty patients with coronary heart disease (CHD) referred to Namazi and Faghihi Hospitals in Shiraz, undergone elective CABG, were enrolled in this study. For evaluation of oxidative stress, whole blood was taken before and 24 hours after surgery and malondialdehyde (MDA) as an oxidative marker and glutathione (GSH) as an antioxidant marker were measured. Results: Results showed a significant difference between the mean concentration of GSH before and after CABG surgery (P <0.05); however, the difference in plasma MDA levels before and after CABG was insignificant. Conclusion: CABG surgery results in oxidative stress and reduces GSH 24h after surgery and administration of antioxidants may attenuate post-operative oxidative stress. [GMJ.2015;4(2):78-82]

Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. Journal of the American College of Cardiology. 2004;44(12):2293-300.

Van Wagoner DR, Nerbonne JM. Molecular basis of electrical remodeling in atrial fibrillation. Journal of molecular and cellular cardiology. 2000;32(6):1101-17.

Villareal RP, Hariharan R, Liu BC, Kar B, Lee V-V, Elayda M, et al. Postoperative atrial fibrillation and mortality after coronary artery bypass surgery. Journal of the American College of Cardiology. 2004;43(5):742-8.

Van Wagoner DR, Pond AL, Lamorgese M, Rossie SS, McCarthy PM, Nerbonne JM. Atrial L-type Ca2+ currents and human atrial fibrillation. Circulation Research. 1999;85(5):428-36.

Mihm MJ, Yu F, Carnes CA, Reiser PJ, McCarthy PM, Van Wagoner DR, et al. Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation. 2001;104(2):174-80.

Davis EM, Packard KA, Hilleman DE. Pharmacologic Prophylaxis of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: Beyond β‐Blockers. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2010;30(7):749-52.

Stanger O, Aigner I, Schimetta W, Wonisch W. Antioxidant Supplementation Attenuates Oxidative Stress in Patients Undergoing Coronary Artery Bypass Graft Surgery. The Tohoku journal of experimental medicine. 2014;232(2):145-54.

Pattwell D, Ashton T, McArdle A, Griffiths RD, Jackson MJ. Ischemia and reperfusion of skeletal muscle lead to the appearance of a stable lipid free radical in the circulation. American Journal of Physiology-Heart and Circulatory Physiology. 2003;284(6):H2400-H4.

Kontos HA. Oxygen radicals in cerebral ischemia the 2001 Willis Lecture. Stroke. 2001;32(11):2712-6.

Yaghoubi A, Farzam S, Pezeshkian M, Golmohammadi Z, Nasiri B, Azarfarin R, et al. Comparison of Oxidative Stress Content During On-pump and Off-pump Coronary Artery Bypass Surgery. Journal of Cardiovascular and Thoracic Research. 2009;1(3):29-34.

Ellman GL. Tissue sulfhydryl groups. Archives of biochemistry and biophysics. 1959;82(1):70-7.

Zal F, Mostafavi-Pour Z, Vessal M. Comparison of the effects of vitamin E and/or quercetin in attenuating chronic cyclosporine A-induced nephrotoxicity in male rats. Clinical and experimental pharmacology & physiology. 2007;34(8):720-4.

Ceconi C, Boraso A, Cargnoni A, Ferrari R. Oxidative stress in cardiovascular disease: myth or fact? Archives of Biochemistry and Biophysics. 2003;420(2):217-21.

Carlucci F, Tabucchi A, Biagioli B, Simeone F, Scolletta S, Rosi F, et al. Cardiac surgery: myocardial energy balance, antioxidant status and endothelial function after ischemia–reperfusion. Biomedicine & pharmacotherapy. 2002;56(10):483-91.

D'souza B, Vishwanath P, D'souza V. Oxidative injury and antioxidants in coronary artery bypass graft surgery: off-pump CABG significantly reduces oxidative stress. Clinica Chimica Acta. 2007;375(1):147-52.

Milei J, Forcada P, Fraga CG, Grana DR, Iannelli G, Chiariello M, et al. Relationship between oxidative stress, lipid peroxidation, and ultrastructural damage in patients with coronary artery disease undergoing cardioplegic arrest/reperfusion. Cardiovascular research. 2007;73(4):710-9.

Sander M, von Heymann C, von Dossow V, Spaethe C, Konertz WF, Jain U, et al. Increased interleukin-6 after cardiac surgery predicts infection. Anesthesia & Analgesia. 2006;102(6):1623-9.

Murkin JM, editor Panvascular inflammation and mechanisms of injury in perioperative CNS outcomes. Seminars in cardiothoracic and vascular anesthesia; 2010: SAGE Publications.

Plomondon ME, Cleveland Jr JC, Ludwig ST, Grunwald GK, Kiefe CI, Grover FL, et al. Off-pump coronary artery bypass is associated with improved risk-adjusted outcomes. The Annals of thoracic surgery. 2001;72(1):114-9.

Altaei T. Protective effect of silymarin during coronary artery bypass grafting surgery. Experimental & Clinical Cardiology. 2012;17(1):34.

Gerritsen W, Van Boven W, Driessen A, Haas F, Aarts L. Off-pump versus on-pump coronary artery bypass grafting: oxidative stress and renal function. European journal of cardio-thoracic surgery. 2001;20(5):923-9.

Gerritsen WB, van Boven W-JP, Boss DS, Haas FJ, van Dongen EP, Aarts LP. Malondialdehyde in plasma, a biomarker of global oxidative stress during mini-CABG compared to on-and off-pump CABG surgery: a pilot study. Interactive cardiovascular and thoracic surgery. 2006;5(1):27-31.

Lazzarino G, Raatikainen P, Nuutinen M, Nissinen J, Tavazzi B, Di Pierro D, et al. Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery. Circulation. 1994;90(1):291-7.

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