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Dietary Nutrients and Male Infertility: Review of Current Evidence

Banafshe Hosseini, Kurosh Djafarian
Lifestyle factors and nutritional status are regarded as critical determinants of normal reproductive function. Hence, the role of dietary nutrients has attracted the attention of researchers to the extent that some studies have addressed the effects of diet on the risk of male infertility. This study aimed to summarize the literature regarding the association between various dietary factors and male infertility. Literature searching for studies on male infertility and nutrition, published between January 1982 and May 2015, was performed using PubMed and Scopus databases. The bibliographies of included studies were also searched for additional references. About 65 articles were identified and after the elimination of irrelevant studies, 35 related studies available for review were examined. Studies have indicated that in men with idiopathic infertility, omega-3 intervention resulted in significant improvement in total sperm count as well as sperm cell density. Moreover, several studies have shown that higher intake of poultry, cereals, fruit and vegetables may play a beneficial role in male infertility; although, some studies have not attained such results. Taken as a whole, studies demonstrated that food consumption may play a major role in preventing or facilitating male infertility. Further studies are needed to clarify this association. [GMJ.2015;4(4):123-29]
Nutrition; Spermatogenesis; Nutrient; Sperm Quality; Male Infertility

Hosseini B, Eslamian G. Association of Dietary Factors With Male and Female Infertility: Review of Current Evidence.Thrita 2014; 3(3):e20953.

Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi MR, Hekmatdoost A. Intake of food groups and idiopathic asthenozoospermia: a case-control study. Hum rep 2012; 27(11):3328-36.

Andersen AG, Carlsen E, Jorgensen N, Andersson AM. High frequency of sub-optimal semen quality in an unselected population of young men. Hum rep 2000; 15:366-72.

Carlsen E GA, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305:609-13.

World Health Organization. WHO Manual for the Standardised Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press, 2000.

Dohle AJ, Colpi A, Giwercman T, Diemer TB. Guidelines on Male Infertility. European Association of Urology 2007.

Hauser R, Southwick GJ, de Kretser DM. Fertility in cases of hypergonadotropic azoospermia. Fert stert 1995;63(3):631-6.

Safarinejad MR, Dadkhah F, Asgari MA. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. Clin Nutr 2010;29:100-5.

Connor KL, Beltrand J, Meaney MJ, Sloboda DM. Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function. J Physiol 2012; 590:2167-80.

Batra N, Bansal MP. Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status. Br J Nutr 2004; 91(3):387-91.

Lioret MS, Crawford D, Spence AC, Hesketh K, Campbell KJ. Parents’ dietary patterns are significantly correlated: findings from the Melbourne Infant Feeding Activity and Nutrition Trial Program. Br J Nutr 2012; 108:518–26.

Mendiola J, Torres-Cantero AM, Moreno-Grau JM, Ten J, Roca M, Moreno-Grau S, et al. Food intake and its relationship with semen quality: a case-control study. Fert stert 2009;91(3):812-8.

Bialostosky WJ, Kennedy-Stephenson J, McDowell M, Johnson CL. Dietary intake of macronutrients, micronutrients, and other dietary constituents: United States 1988–94. Vit Hlth Stat 2002; 11:1-158.

Bongalhardo LS, Buhr MM. Dietary lipids differentially affect membranes from different areas of rooster sperm. Poul Sci 2009; 88:1060-9.

Tavilani DM, Abdi K, Vaisiraygani A, Joshaghani HR. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. Andrologia 2006;38:173-8.

Mazza MP, Janiri L, Bria P,Mazza S. Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: an overview. Prog Neuropsycho pharmacol Biol Psychiatry 2007;31:12-26.

Lenzi GL, Maresca V, Rago R, Sgro P. Fatty acid composition of spermatozoa and immaturengerm cells. Mol Hum Reprod 2000; 6:226-31.

Conquer MJ, Tummon I, Watson L, Tekpetey F. Fatty acid analysis of blood serum, seminal plasma, and spermatozoa of normozoospermic vs. asthenozoospermic males. Lipids 1999; 34:793-9.

Attaman JA, Campos H, Hauser R. Dietary fat and semen quality among men attending a fertility clinic. Hum Rep 2012;27:1466-74.

Eslamian G, Rashidkhani B, Sadeghi MR, Hekmatdoost A. Effects of combined supplementation with vitamin E and docosahexaenoic acid on oxidative stress markers in seminal plasma in asthenozoospermic men. Polyhedron J 2013;18(5):222-31.

Conquer JA, Tummon I, Watson L, Tekpetey F. Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males. Lipids 2000;35:149-54.

Swan SH, Overstreet JW, Brazil C, Skakkebaek NE. Semen quality of fertile US males in relation to their mothers’ beef consumption during pregnancy. Hum rep 2007;22:1497-502.

Braga DP, Halpern G, Figueira Rde C, Setti AS, Iaconelli A, Borges E. Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes. Fert stert 2012;97(1):53-9.

Vujkovic M, Dohle GR, Bonsel GJ, Lindemans J, Macklon NS, Steegers EA, et al. Associations between dietary patterns and semen quality in men undergoing IVF/ICSI treatment. . Hum Rep [Oxford, England] 2009;24:1304-12.

Chavarro JE, Toth TL, Sadio SM, Hauser R. Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic. Hum rep 2008;23(11):2584-90.

Song KL, Andolina E, Herko RC, Brewer KJ, Lewis V. beneficial effects of dietary intake of plant phytoestrogens on semen parameters and sperm DNA integrity in infertile men. Fert stert 2006; 86:49-56.

Kuiper G, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S , et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and b. Endocrin 1997;138:863-70.

Atanassova M, Turner K, Walker M, Fisher J, Morley M, Millar M, et al. Comparative effects of neonatal exposure of male rats to potent and weak [environmental] estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels. Endocrin 2000;141:3898–907.

Glasier AF, Irvine DS, Wickings EI, Hiller SG and Baird DA. A comparison of the effects on follicular development between clomiphene citrate, its two separate isomers and spontaneous cycles. Human Rep 1989;4:252-6.

Harrington JM. Occupational exposure to synthetic estrogens: some methodological problems. Work Environ Health 1982.1:167-71.

Mattison DR, Plowchalk DR, Meadows MJ, Aljuburi AZ, Gandy J and Malek A. Reproductive toxicity : male and female reproductive systems as targets for chemical injury. Med Clin North Am 1990;74: 391-411.

Faber CL. The effect of neonatal exposure to diethylstilbestrol, genistein and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. Biol Reprod 1991;45:649-53.

Julie H, Mitchel EC, Kinniburgh D, Provan A, Collin A, Irvine DS. Effect of a phytoestrogen food supplement on reproductive health in normal males. Clinical Science 2001:613-18.

Lewis V KL, Herko R, Brewer E, Andolina G, Song G. Dietary antioxidants and sperm quality in infertile men. American Society of Reproductive Medicine Annual Meeting, New Orleans, LA, October 21–25: Fertil Steril 2006; 364.

Gaskins AJ, Colaci DS, Mendiola J, Swan SH, Chavarro JE. Dietary patterns and semen quality in young men. Hum repr 2012;27(10):2899-907.

Gorbach SL. Diet and the excretion and enterohepatic cycling of estrogens. Prev Med 1987;16:525-31.

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