A 9-Year Old Boy with Leukemia and Oral Manifestation: A Case Report and Review of Literature

  • Alieh Safari Tehran University of Medical Sciences
  • Farzad Kompani Tehran University of Medical Sciences
  • Sara Memarian Tehran University of Medical Sciences
  • Maryam Monajemzadeh Tehran University of Medical Sciences
  • Rahman Khosravi Tehran University of Medical Sciences
  • Behdad Gharib Tehran University of Medical Sciences
Keywords: Leukemia, Acute Lymphoblastic, Oral Manifestations, Histiocytosis, Langerhans Cell


Background: Childhood leukemia is not a common disease. However, the most common malignant neoplasms in children are the leukemias, and 77% of these cases are acute lymphoblastic leukemia (ALL). Case Report: We report a case of precursor B-cell ALL, initially presented by unusual manifestations such as; teeth ache, loose teeth and gum swelling, knee pain and a normal cell blood count (CBC). It was first considered to be Histiocytosis. Several laboratory workups have been performed to rule out the immunologic, infectious and rheumatologic diseases. A bone marrow aspiration revealed the diagnosis of leukemia. However, acute myeloid leukemia is more famous for being accompanied by oral presentation; our patient was afflicted by ALL. The patient was first referred to a dentist for the oral manifestations. Conclusion: This case reminds the importance of systemic evaluation of localized signs and symptoms in children and detailed history taking, follow-ups and physical examination.[GMJ.2016;5(4):215-18]


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How to Cite
Safari, A., Kompani, F., Memarian, S., Monajemzadeh, M., Khosravi, R., & Gharib, B. (2016). A 9-Year Old Boy with Leukemia and Oral Manifestation: A Case Report and Review of Literature. Galen Medical Journal, 5(4), 215-18. https://doi.org/10.31661/gmj.v5i4.576
Case Report/Series