Effects of Flaxseed Oil Consumption on Anthropometric Parameters in the Patients with Metabolic Syndrome: A Randomized Clinical Trial

  • Atefeh Akrami
  • Farzad Nikaein Nutrition and Food Sciences Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Siavash Babajafari
  • Shiva Faghih
  • Mohammad Javad Zibaeenejad
Keywords: Metabolic Syndrome, Body Weight, Waist Circumference, Linseed Oil, Linoleic Acid


Background: Flaxseed oil, as the main source of Alpha linolenic acid (ALA), decreases the production of Arachidonic acid (AA) from linoleic acid (LA) that plays an important role in the development of metabolic syndrome (MS). The aim of the present study was to compare the effects of flaxseed oil and sunflower oil on anthropometric parameters in patients suffering from MS. Materials and Methods: In this randomized clinical trial, 60 participants aged 30-60 years who suffered from MS were selected according to ATP III definition and were divided into two even groups receiving flaxseed oil and sunflower oil. Each group received 25 ml of the specified oil on a daily basis for 7 weeks. The anthropometric measures were evaluated on the first and last days of the study. Results: No significant differences were observed between the two groups regarding weight. However, waist circumference reduced significantly in the flaxseed oil group compared to the control group (P=0.001). Conclusions: The ALA might prevent the increase in adipose tissues. Therefore, it seems that flaxseed oil has beneficial effects on MS. [GMJ.2017;6(1):44-51]


Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC. Fruit and vegetable intakes, C-reactive protein, and the metabolic Syndrome. Am J ClinNutr. 2006;84(6):1489-97.

Noori N, Mirmiran P, Asgari S, Azizi F. Dietary Intake of Calcium and Vitamin D and the Prevalence of Metabolic Syndrome in Tehranian Adults: Tehran Lipid and Glucose Study (TLGS). Ir J endo & metab. 2007;9:1.

Ervine RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: united states, 2003–2006. Natl Health Stat Report. 2009;5(13):1-7.

Sharghi S. Metabolic syndrome and obesity. Iranian Journal of Diabetes and Metabolism. 1392;5(51):399-412.

Chiheb S, Cosson E, Banu I, Hamo-Tchatchouang E, Cussac-Pillegand C. Are Obese Individuals with no Feature of Metabolic Syndrome but Increased Waist Circumference Really Healthy? A Cross Sectional Study. Exp Clin Endocrinol Diabetes. 2016;124(7):410-6.

Hu H, kurotani K, Sasaki N, Murakami T, Shimizu C, Shimizu M. Optimal waist circumference cut-off points and ability of different metabolic syndrome criteria for predicting diabetes in Japanese men and women: Japan Epidemiology Collaboration on Occupational Health Study. BMC Public Health. 2016;16:220.

Neill SO, Driscoll LO. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. obes Rev. 2015;16(1):1-12.

Babio N, nicabullo M, Salas-Salvado J. Mediterranean diet and metabolic syndrome: the evidence 2009. Public Health Nutr. 2009;12(9A):1607-17.

Akter SH, Nanri A, Minh Pham N, Kurotani K, Mizoue T. Dietary patterns and metabolic syndrome in a Japanese working population. Nutr Metab. 2013;10(30):1-10.

Hosseinpour-Niazi S, Fallah A, Mirmiran P, Azizi F. Association between macronutrients and metabolic syndrome among adults. Pejouhandeh. 2013;18(1):23-9.

Poudyal H, Panchal SK, Diwan V, Brown L. Omega-3 fatty acids and metabolic syndrome: Effects and emerging mechanisms of action. Prog Lipid Res. 2011;50(4):372–87.

Enns JE, Hankeb D, Park A, Zahradka P, Taylor CG. Diets high in monounsaturated and polyunsaturated fatty acids decrease fatty acid synthase protein levels in adipose tissue but do not alter other markers of adipose function and inflammation in diet-induced obese rats. Prostaglandins Leukot Essent Fatty Acids. 2014;90(2-3):77-84.

Hammad S, Pu S, Jones PJ. Current evidence supporting the link between dietary fatty acids and cardiovascular disease. Lipids. 2016;51(5):507-17.

Third Report of the National Education Program (NCEP) Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adult (Adult Treatment Panel) final report. 2002;106(25):3143-421.

Hosseinpour-Niazi S, Mirmiran P, Naderi Z, sadeghi M, Azizi F. Association between intake of polyunsaturated fatty acids and the metabolic syndrome and its components among adults: Tehran Lipid and Glucose Study. Research in Medicine. 2012;35(4):225-36.

Ghosh A, Bose K, Das Chaudhuri AB. Association of food patterns, central obesity measures and metabolic risk factors for coronary heart disease (CHD) in middle aged Bengalee Hindu men, Calcutta, India. Asia Pac J Clin Nutr. 2003;12(2):166-71.

Prasad K. Dietary flaxseed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis.1997;132(1):69-76.

Tint D, Anghel M, Lupu DS, Fischer LM, Niculescu MD. Low dose flaxseed oil supplementation alters the fatty acids profile and the progression of metabolic syndrome in men without adequate medical treatment. J Nutr Disorders. 2011 Ther S7:001.

Vijaimohan K, Jainu M, Sabitha KE, Subramaniyam S, Anandhan C, Shyamala Devi CS. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. Life Sci. 2006;79(5):448-54.

Pouteau E, Aprikian O, Grenot C, Reynaud D, Pace-Asciak C, Cuilleron CY, et al. A low a-linolenic intake during early life increases adiposity in the adult guinea pig. Nutr & Metabo. 2010;7(8):1-9.

How to Cite
Akrami, A., Nikaein, F., Babajafari, S., Faghih, S., & Zibaeenejad, M. J. (2017). Effects of Flaxseed Oil Consumption on Anthropometric Parameters in the Patients with Metabolic Syndrome: A Randomized Clinical Trial. Galen Medical Journal, 6(1), 44-51. https://doi.org/10.31661/gmj.v6i1.582
Original Article