A Review of Herbal Medicines for Nausea and Vomiting of Pregnancy in Traditional Persian Medicine

  • Shahrbanoo Abdolhosseini Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran
  • Fataneh Hashem Dabaghian Community Medicine Specialist, Research Institute for Islamic & Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Mitra Mehrabani Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • Roshanak Mokaberinejad Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Keywords: Nausea, Vomiting, Pregnancy, Traditional Medicine, Morning Sickness


Nausea and vomiting of pregnancy (NVP) is one of the prevalent pregnancy complaints. This study was conducted to review the medicinal plants mentioned in Traditional Persian Med­icine (TPM) for the treatment of NVP. A literature research was conducted on a number of main references of TPM, including the books of al-Qanun fī al-Teb, Zakhireye Kharazmshahi, Tadbir-al-Habali al- Atfal al-Sabiban and Makhzan-al-Adviah. Then, medicinal plants mentioned in TPM for treatment of NVP were determined and searched in electronic databases, including PubMed and Google Scholar to find studies that confirmed their efficacy. The search terms were ‘‘vomiting’’ or ‘‘nausea’’ or “emesis” and “pregnancy” and the name of each herb. Data were collected for the years 1990–2016. The findings included 10 plants. Citrus limon (Lemon), Citrus medica L. (Citron), Cydonia oblonga (Quince), Elletaria cardamomum (Cardamom), Mentha spicata L. (Spearmint), Menatha piperita (Mint), Myristica fragrans Houtt (Nutmeg), Pistacia lentiscus Linn. (Mastic), Punica granatum L. (Pomegranate), Malus domestica Borkh (Apple), and Piper cubeba L. are the most recommended medications for NVP. There is evidence in human studies for some of these medicinal plants (Mentha Piperita L., Citrus limon, Elletaria cardamom, and Cydonia oblonga Mill). The other mentioned herbs have not been evaluated during pregnancy. There is limited evidence to safely recommend these plants for NVP. Although some human studies have suggested the antiemetic effects of TPM remedies, their safety is not sufficiently documented in modern literature. Scientific studies on these medicinal plants during pregnancy are warranted to determine their safety. [GMJ.2017;6(4):281-90] DOI: 10.22086/gmj.v0i0.809


Matthews A, Haas DM, O’Mathúna DP, Dowswell T, Doyle M. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2014 Jan 1;3.

Davis MP, RN. Nausea and Vomiting of Pregnancy: An Evidence‐based Review. J Perinat Neonatal Nurs. 2004;18(4):312-28.

Herrell HE. Nausea and vomiting of pregnancy. Am Fam Physician. 2014;89(12):965-70.

Thomas B, Rouf PVA, Al-Hail M, al Saad D, Tharannum A. Medication used in Nausea and Vomiting of Pregnancy-A Review of Safety and Efficacy. Gynecology & Obstetrics. 2015.

. Anderka M, Mitchell AA, Louik C, Werler MM, Hernández‐Diaz S, Rasmussen SA. Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. Birth Defects Res A Clin Mol Teratol. 2012;94(1):22-30.

World Health Organization. National policy on traditional medicine and regulation of herbal medicines: Report of a WHO global survey.

Hashem Dabaghian F, Taghavi Shirazi M, Amini Behbahani F, Shojaee A. Interventions of Iranian Traditional Medicine for Constipation During Pregnancy. Jmp 2015; 1(53):58-68.

. Zargaran A, Mehdizadeh A, Zarshenas MM, Mohagheghzadeh A. Avicenna (980–1037 AD). J Neurol. 2012;259(2):389-90.

Zarshenas MM, Zargaran A, Abolhassanzadeh Z, Vessal K. Jorjani (1042–1137). J Neurol. 2012:1-2.

Fleming T. PDR for herbal medicines. USA: Thomson health care Inc. 2000: 87, 235, 461,476,508, 547,605, 626, 709.

Gardner Z, McGuffin M , Botanical Safety; Second Edition, CRC Press; 2013: 232, 328, 562, 569, 588, 663, 718 .

Amin G. Popular Medicinal Plant of Iran.Tehran: Tehran University of Medical Sciences. 2005: 124, 216, 260, 262.

Arzani M. Mufarrih al-qulub. Tehran, Almaee publications. 2012: 860.

Albaladi A. Tadbir-al-Habali,al- Atfal, al-Sabiban. Baghdad, Dar Al-Rashid pub. 1980: 151.

Aghili Shirazi MH. Makhzan-al-advia( Persian). Tehran: Tehran University of Medical Sciences; 2011: 122, 260,302. 415-16, 458, 604, 652, 669, 713, 743, 773.

Safajou F, Shahnazi M, Nazemiyeh H. The effect of lemon inhalation aromatherapy on nausea and vomiting of pregnancy: a double-blinded, randomized, controlled clinical trial. Iran Red Crescent Med J. 2014;16(3).

. Pasha H, Behmanesh F, Mohsenzadeh F, Hajahmadi M, Moghadamnia AA. Study of the effect of mint oil on nausea and vomiting during pregnancy. Iran Red Crescent Med J. 2012;14(11):727.

ozgholy g, gharayagh zandi m, nazem ekbatani n, allavi h, moattar f. Cardamom powder effect on nausea and vomiting during pregnancy. complementary Medicine Journal. 2015;5(1):1065-76.

Rozza AL, de Mello Moraes T, Kushima H, Tanimoto A, Marques MOM, Bauab TM, et al. Gastroprotective mechanisms of Citrus lemon (Rutaceae) essential oil and its majority compounds limonene and β-pinene: involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, sulfhydryl compounds, nitric oxide and prostaglandin E 2. Chem Biol Interact. 2011;189(1):82-9.

. Jorjani, L., Zakhireh Kharazmshahi, Qom: Institute for natural medicine; Vol: 2; 2012: 940.

Moraes TM, Rozza AL, Kushima H, Pellizzon CH, Rocha LRM, Hiruma-Lima CA. Healing actions of essential oils from Citrus aurantium and d-limonene in the gastric mucosa: the roles of VEGF, PCNA, and COX-2 in cell proliferation. J Med Food. 2013;16(12):1162-7.

Khoubnasabjafari M, Jouyban A. A review of phytochemistry and bioactivity of quince (Cydonia oblonga Mill.). Journal of Medicinal Plants Research. 2011;5(16):3577-94.

Aghili Khorasani M. Khulaṣat al-ḥikmah. Qom: Esmailian publications. 2006,v:2, p: 147.

Jafari Dehordi E. Comparison of’Cydonia Oblonga’fruit product with B6 on nausea and vomiting in pregnancy (Doctoral dissertation, Doctorate Thesis]. Tehran, Iran: School of Traditional Medicine, Iran University of Medical Sciences).

De Pradier E. A trial of a mixture of three essential oils in the treatment of postoperative nausea and vomiting. International Journal of Aromatherapy. 2006 Dec 31;16(1):15-20.

Hunt R, Dienemann J, Norton HJ, Hartley W, Hudgens A, Stern T, et al. Aromatherapy as treatment for postoperative nausea: a randomized trial. Anesthesia & Analgesia. 2013;117(3):597-604.

Zulfiker AH, Ahmed D, Alam MB, Saha MR, Saha SK, Khalil MI, Menon TM, Rana MS. Phenolic content and in vitro antioxidant potential of selected medicinal plants of Bangladesh. Journal of Pharmacy Research Vol. 2011 Jul;4(7):1991-8.

Oyedemi TO, Lawal TO, Adeniyi BA. Effect of Myristica fragrans Houtt. Seed (Nutmeg) on Helicobacter pylori induced gastritis in albino rats: in vitro and in vivo studies. International Journal of Biological and Chemical Sciences. 2015;8(4):1355-67.

Razi, M., Al-Hawi. Beirot: Al-Hawi Pharma., 1422. Vol. 6. 385.

Marone P, Bono L, Leone E, Bona S, Carretto E, Perversi L. Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori. J Chemother. 2001;13(6):611-4.

Batista ALA, Lins RDAU, de Souza Coelho R, do Nascimento Barbosa D, Belém NM, Celestino FJA. Clinical efficacy analysis of the mouth rinsing with pomegranate and chamomile plant extracts in the gingival bleeding reduction. Complement Ther Clin Pract. 2014;20(1):93-8.

Abdolhosseini S, Hashem-Dabaghian F, Mokaberinejad R, Sadeghpour O, Mehrabani M. Effects of Pomegranate and Spearmint Syrup on Nausea and Vomiting During Pregnancy: A Randomized Controlled Clinical Trial. Iranian Red Crescent Medical Journal. 2017.

Colombo E, Sangiovanni E, Dell'Agli M. A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evid Based Complement Alternat Med. 2013.

Zaidi SFH, Yamada K, Kadowaki M, Usmanghani K, Sugiyama T. Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J Ethnopharmacol. 2009;121(2):286-91.

Nahak G, Sahu RK. Phytochemical Evaluation and Antioxidant activity of Piper cubeba and Piper nigrum.

Aliasl F, Toliyat T, Aliasl J, Minaee M-B. Nausea and vomiting remedies in Iranian Traditional Medicine (ITM). Iran J Public Health. 2015;44(8):1164-5.

Jafari-Dehkordi E, Mokaberinejad R, Minaei B, Sohrabvand F, Nazem E, Dabaghian FH, et al. A Review of Pioneer Physicians’ Work on Maternal Health in Pregnancy in Ancient Iran; Narrative Systematic Review. Iran J Public Health. 2013;42(12):1340.

Jahromi MM, Pasalar M, Afsharypuor S, Choopani R, Mosaddegh M, Kamalinejad M et al. Preventive care for gastrointestinal disorders; role of herbal medicines in traditional persian medicine. Jundishapur J Nat Pharm Prod. 2015;10:4.

Sattari M, Dilmaghanizadeh M, Hamishehkar H, Mashayekhi SO. Self-reported use and attitudes regarding herbal medicine safety during pregnancy in Iran. Jundishapur J Nat Pharm Prod. 2012;7(2):45-9.

Yamini EA. Some questions about herbal and traditional medicine. Nurs Midwifery Stud 2014. 3(1).

How to Cite
Abdolhosseini, S., Hashem Dabaghian, F., Mehrabani, M., & Mokaberinejad, R. (2017). A Review of Herbal Medicines for Nausea and Vomiting of Pregnancy in Traditional Persian Medicine. Galen Medical Journal, 6(4), 281-290. https://doi.org/10.31661/gmj.v6i4.809
Review Article