Deep Vein Thrombosis, Demographic Characteristics and Risk Factors in Iran

Shokoufeh Hajsadeghi, Scott Reza Jafarian Kerman, Rashin Joodat, Maral Hejratie, Helen Vaferi, Negin Farsi, Khatereh Masoumi, Mehrdad Joorgholami

Background: Deep vein thrombosis (DVT) can be an ethnicity related disease and an important health issue for health-care systems. Thus, domestic recognition of risk factors and disease characteristics seem to be inevitable. This study was designed to evaluate the epidemiology, basic characteristics, and risk factors in patients with DVT.

Materials and Methods: In this descriptive cross-sectional study, all patients with primary or final diagnosis of DVT, confirmed by Doppler ultrasound in a 5-year period were included. Demographic data and prognosis were extracted from medical files. To evaluate the outcome of the patients after discharge, a phone-call follow-up was performed for all available patients.

Results: Three-hundred seventy-one DVT patients were included with 232/139 male to female ratio. The mean age was 55.72±20.01 years with significant difference between genders (p=0.006). Mean weight was 88.97±10.2 kg with no significant difference between genders (p=0.74). The most common affected veins were common femoral vein (257 cases, 69.2%), followed by Popliteal, iliac, axillary, and subclavian veins. No season preference was seen in DVT occurrence. One-year survival of the patients after discharge was 92.6% and two-year survival was 87.7%.

Conclusion: By knowing local information about this disease, health-care providers can give accurate warnings and suggestions to prevent the probable thrombosis chances. As Iran lacked information about DVT characteristics, this study can be an epidemiologic guide for health-care systems and an opening path for future studies.
Deep vein thrombosis; risk factors; survival; Iran

Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrom J. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007; 5: 692–9.

White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107: I4-I8.

Bulger CM, Jacobs C, Patel NH. Epidemiology of acute deep vein thrombosis. Tech Vasc Interv Radiol. 2004; 7(2):50-4.

Roberts LN, Patel RK, Chitongo P, Bonner L, Arya R. African-Caribbean ethnicity is associated with a hypercoagulable state as measured by thrombin generation. Blood Coagulation and Fibrinolysis. 2012; 24(1): 40-49.

Pai N, Ghosh K, Shetty S. Cause of deep venous thrombosis and pulmonary embolism in young patients from India as compared with other ethnic groups. Blood Coagulation and Fibrinolysis. 2012 Jun;23(4):257-61.

Kniffin WDJ, Baron JA, Barrett J, Birkmeyer JD, Anderson FAJ. The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly. Arch Intern Med. 1994;154:861-866.

Heit JA. Venous thromboembolism epidemiology: implications for prevention and management. Semin Thromb Hemost. 2002 Jun;28 (Suppl 2):3-13.

White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I4-8.

Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet. 2012;379(9828):1835-46.

Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158(6):585-93.

Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44(2):62-9.

Anderson Jr, Frederick A, H. Brownell W, Robert JG, David WH, Nilima AP, Borko J, Ann F, Dalen JE. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991;151:933-938.

Nordström M, Lindblad B, Bergqvist D, Kjellström T. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med. 1992;232:155–160.

Ismail K, Aoun E, SleimanZadeAsfahani W, Taher A. Nine years experience at the AUB-MC vascular lab. J Thrombo Haemo. 2003; 1 (Supplement 1 July): 1379

Prandoni P, Villalta S, Bagatella P, Rossi L, Marchiori A, Piccioli A, Bernardi E, Girolami B, Simioni P, Girolami A. The clinical course of deep-vein thrombosis. Prospective long-term follow-up of 528 symptomatic patients. Haematologica. 1997; 82(4):423-8.

Martín-Carbonero L, Salgado X, Pedrajas JM, Armengol JG, Jiménez Rodríguez-Madridejos R, Fernández-Cruz A. Short-term and long-term evolution of deep vein thrombosis treated by a health care unit. Rev Clin Esp. 2002; 202(8):430-4.

Ray JG, Chan WS. Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation. Obstet Gynecol Surv. 1999;54(4):265-71.

Ikard RW, Ueland K, Folse R. Lower limb venous dynamics in pregnant women. Surg Gynecol Obstet. 1971;132:483-488.

Macklon NC, Greer IA, Bowman AW. An ultrasound study of gestational and postural changes in the deep venous system of the leg in pregnancy. Br J Obstet Gynecol. 1997;104:191-197

Metcalfe J, Ueland K. Maternal cardiovascular adjustments to pregnancy. Prog Cardiovasc Dis. 1974;16:363-374.

Kerr MG, Scott DB, Samuel E. Studies of the inferior vena cava in late pregnancy. Br Med J. 1964;1:532-533.

Chau KY, Yuen ST, Wong MP. Clinicopathological pattern of pulmonary thromboembolism in Chinese autopsy patients: comparison with Caucasian series. Pathology. 1997;29(3):263-6.

Wroblewski BM, Siney P, White R. Seasonal variation in fatal pulmonary embolism after hip arthroplasty. Lancet. 1990;335:56.

Gallerani M, Manfredini R, Ricci L, Grandi E, Cappato R, Calo G, Pareschi PL, Fersini C. Sudden death from pulmonary thromboembolism: chronobiological aspects. Eur Heart J. 1992;13:661–665.

Bounameaux H, Hicklin L, Desmarais S. Seasonal variation in deep vein thrombosis. BMJ. 1996;312:284–285.

Boulay F, Berthier F, Schoukroun G, Raybaut C, Gendreike Y, Blaive B. Seasonal variations in hospital admission for deep vein thrombosis and pulmonary embolism: analysis of discharge data. BMJ. 2001; 323: 601–602.

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