Efficacy of Traditional Persian Medicine-Based Diet on Non-Alcoholic Fatty Liver Disease: A Randomized, Controlled, Clinical Trial

  • Gholam Reza Ghayour Razmgah Ph.D. Candidate, faculty of Iranian Traditional Medicine and Complementary Medicine, Mashhad University Medical of Sciences, Mashhad, Iran
  • Seyed Mousal-Reza Hosseini Department of Gastroenterology and Hepatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Nematy Department of Nutrition School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Habibollah Esmaily Health Sciences Research Center, Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mahdi Yousefi Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Kamalinejad School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Seyed Hamdollah Mosavat Research Centre for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Keywords: Non-Alcoholic Fatty Liver Disease, Diet, Traditional Medicine, Clinical Trial


Background: Regarding the preventive approaches of traditional Persian medicine (TPM) in the management of chronic diseases such as fatty liver, we evaluated the effect of a TPM-based nutritional style on liver enzymes levels and fatty liver grade in patients with non-alcoholic fatty liver. Materials and Methods: Patients were randomly assigned to receive either a three-month TPM-based diet as the intervention group or received the low-fat, low-calorie diet as the control group. The primary outcome measure was changes in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Secondary outcome measures were changes in fatty liver grade (fatty tissue infiltration in liver by using ultrasound imaging) and changes in patients’ body mass index (BMI). All outcome measures were evaluated at the baseline, at six weeks, and at three months after intervention. Results: Regarding within-group changes in outcome measures’ mean values, there was a significant reduction in ALT serum level, AST, BMI, and fatty liver grade after intervention, compared with baseline in both groups of study (P< 0.001). The results of between-group analyses showed significant decreases in both mean body mass index and mean fatty liver grade between the intervention group compared to the control group at the end of intervention (P<0.037 and P<0.003, respectively). Conclusion: This randomized open-label controlled clinical trial demonstrated that the traditional Persian medicine-based nutritional style, used as a non-pharmacological remedy, could reduce body weight and improve fatty liver grade in patients suffering from non-alcoholic fatty liver disease. [GMJ.2017;6(3):208-216] DOI:10.22086/gmj.v6i3.813


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How to Cite
Ghayour Razmgah, G. R., Hosseini, S. M.-R., Nematy, M., Esmaily, H., Yousefi, M., Kamalinejad, M., & Mosavat, S. H. (2017). Efficacy of Traditional Persian Medicine-Based Diet on Non-Alcoholic Fatty Liver Disease: A Randomized, Controlled, Clinical Trial. Galen Medical Journal, 6(3), 208-216. https://doi.org/10.31661/gmj.v6i3.813
Original Article