Chicory Aroma Water for Neonatal Jaundice: A Randomized Clinical Trial

  • Mohsen Manouchehrian Department of Traditional Medicine, Faculty of Traditional Persian medicine, Shahid SadoughiUniversity of Medical Sciences,Ardakan, Yazd, Iran
  • Mehrdad Shakiba Pediatric Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mamak Shariat Maternal, Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Kamalinejad School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mehdi Pasalar Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Ali Akbar Jafarian Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran
  • Mohammad Hassan Lotfi Department of Biostatistics & Epidemiology, Health Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Naeimeh Keighobady Department of Biostatistics and Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Keywords: Chicorium intybus, Phototherapy, Neonatal jaundice, Pregnancy, Traditional medicine, Persia, Prevention


Background: Although neonatal jaundice occurs in 60% of term infants, very little evidence is available on how to prevent it. Given the ethno-medical use of chicory aroma water (CAW) for the management of jaundice by Iranian pregnant women, the aim of this study was to evaluate whether the frequent CAW consumption was associated with fewer jaundice symptoms after 40 days. Materials and Methods: A single blind randomized controlled trial was designed to enroll participants from Lolagar Hospital, Tehran, Iran. Pregnant women (n=80) were randomly divided into two groups. The trial group was provided with common diet and an instruction to consume CAW. The control group was maintained on common diet. The proportion of phototherapy and mean value of bilirubin were measured and compared between the two groups. (IRCT registry number: IRCT2017041633475N1) Results: There was no statistically significant difference in the mean value of bilirubin between the women with frequent CAW consumption compared with the control. Also, the intake of CAW was not associated with a marked improvement in the need for phototherapy (P > 0.05). Conclusion: The findings of this study highlighted that the intake of CAW by pregnant women failed to ameliorate neonatal jaundice.[GMJ.2017;6(4):312-8] DOI: 10.22086/gmj.v6i4.973


Kliegman RM, Stanton BF, St Geme JW, Scor NF. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: ELSEVIER; 2015.

Vreman HJ, Wong RJ, Stevenson DK. Phototherapy: current methods and future directions. Semin perinatol. 2004;28(5):326-33.

Najib KS, Saki F, Hemmati F, Inaloo S. Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in the South of iran (fars province). Iran Red Crescent Med J. 2013;15(3):260-3.

Bhutani VK, Wong RJ. Bilirubin neurotoxicity in preterm infants: risk and prevention. J Clin Neonatol. 2013;2(2):61-9.

Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2008;358(9):920-8.

Amirshaghaghi A, Ghabili K, Shoja MM, Kooshavar H. Neonatal jaundice: knowledge and practice of Iranian mothers with icteric newborns. Pak J Biol Sci. 2008;11(6):942-5.

Ebrahimimd S, Ashkani-Esfahani S, Poormahmudibs A. Investigating the efficacy of zizyphus jujuba on neonatal jaundice. Iran J Pediatr. 2011;21(3):320-4.

Basiri-Moghadam M, Basiri-Moghadam K, Kianmehr M, Jani S. The effect of massage on neonatal jaundice in stable preterm newborn infants: a randomized controlled trial. J Pak Med Assoc. 2015;65(6):602-6.

Khera S, Gupta R. Incidence of thrombocytopenia following phototherapy in hyperbilirubinemic neonates. Med J Armed Forces India. 2011;67(4):329-32.

Behjati S, Sagheb S, Aryasepehr S, Yaghmai B. Adverse events associated with neonatal exchange transfusion for hyperbilirubinemia. Indian J Pediatr. 2009;76(1):83-5.

Nabavizadeh SH, Safari M, Khoshnevisan F. The effect of herbal drugs on neonatal jaundice. Iran J Pediatr. 2005;15(2):133-8.

Heydari M, Heydari H, Saadati A, Gharehbeglou M, Tafaroji J, Akbari A. Ethnomedicine for neonatal jaundice: A cross-sectional survey in Qom, Iran. J Ethnopharmacol. 2016;193:637-42.

Davies GA, Maxwell C, McLeod L, Gagnon R, Basso M, Bos H, et al. Obesity in pregnancy. J Obstet Gynaecol Can. 2010;32(2):165-73.

Ibn Sina AAH. Al Qanun Fi al-Tibb. Lebanon: Alamy Le- Al-Matbooat Institute; 2005. [In Arabic]

Kim M, Shin HK. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. J Nutr. 1998;128(10):1731-6.

Shoorideh H, Peighambari SA, Omidi M, Naghavi MR, Maroufi A. Assessing Potential of Iranian Chicory Genotypes for Industrial Application. Inter J Hortic Sci Technol. 2016;3(1):59-68.

Mohammadi Q, Minae MB, Somi MH, Mosaddegh M, Kamalinejad M. Novel Use of Chicory for the Treatment of Hiccups in Liver Obstruction: In Iranian Traditional Medicine. Iran Red Crescent Med J. 2013;15(11):e6647.

Jorjani E. Zakhireye Kharazm Shahi (Treasure of Kharazm Shah). Tehran: Iranian Medical Academy; 2001. [In Persian].

Aghili Shirazi MH. Makhzan-al-advia (Persian). Tehran: Tehran University of Medical Sciences; 2009.

Aghili M. Kholase al hekmah. Quom: Esmailian. 2006;1:335-62.[In Persian]

Okwundu CI, Okoromah CA, Shah PS. Cochrane Review: Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants. Evid Based child health. 2013;8(1):204-49.

Boskabadi H, Maamouri G, Mafinejad S. The Effect of Traditional Remedies (Camel's Thorn, Flixweed and Sugar Water) on Idiopathic Neonatal Jaundice. Iran J Pediatr. 2011;21(3):325-30.

Panahandeh G, Khoshdel A, Sedehi M, Aliakbari A. Phytotherapy with Hordeum Vulgare: A Randomized Controlled Trial on Infants with Jaundice. J Clin Diagn Res. 2017;11(3):Sc16-sc9.

Das S, Vasudeva N, Sharma S. Cichorium intybus: A concise report on its ethnomedicinal, botanical, and phytopharmacological aspects. Drug Dev Ther. 2016;7(1):1.

Zahedpasha Y, Ahmadpour-Kacho M, Hajiahmadi M, Naderi S. Effect of clofibrate in jaundiced full-term infants:a randomized clinical trial. Arch Iran Med. 2007;10(3):349-53.

Ferretti G, Cester AM, Bacchetti T, Raffaelli F, Vignini A, Orici F, et al. Leptin and paraoxonase activity in cord blood from obese mothers. J Matern Fetal Neonatal Med. 2014;27(13):1353-6.

Ibn Nafis A. Al-shamel fi Sana'at tebbi'at [Arabic]. Tehran: The Institute for Medical History-Islamic and Complementary Medicine, Iran University of Medical Sciences; 2008.

Mosaffa-Jahromi M, Pasalar M, Afsharypuor S, Choopani R, Mosaddegh M, Kamalinejad M, et al. Preventive care for gastrointestinal disorders; role of herbal medicines in traditional persian medicine. Jundishapur J Nat Pharm Prod. 2015;10(4).

How to Cite
Manouchehrian, M., Shakiba, M., Shariat, M., Kamalinejad, M., Pasalar, M., Jafarian, A. A., Lotfi, M. H., & Keighobady, N. (2017). Chicory Aroma Water for Neonatal Jaundice: A Randomized Clinical Trial. Galen Medical Journal, 6(4), 312-318.
Original Article